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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Sheep antibody to beta synuclein (108-125): whole serum/S-041-100/100 µl
商品描述
| Description | Beta-synucleinisanon-amyloidcomponentofsenileplaquesfoundinAlzheimerdisease.ItcouldactasaregulatorofSNCAaggregation.Itprotectsneruronsfromstaurosporineand6hydroxydopamine-stimulatedcapspaseactivationinap53-dependentmanner.Itlocalisestothecytoplasmanditispredominantlyexpressedinthebrainwhereitismostconcentratedinpresynapticnerveterminals.Thisproteinisphosphorylated.ThisproteinisalsoassociatedwiththediseaseBrainironaccumulationtype1(NBIA1). |
| BatchNo. | Seeproductlabel |
| Unitsize | 100µl |
| Antigen | Asyntheticpeptide(IEPLMEPEGSYEDPPQE)aspartofhumanbetasynucleinprotein(aa:108-125)conjugatedtodiphteriatoxidhasbeenusedastheimmunogen. |
| OtherNames | SNCB |
| Accession | SYUB_HUMAN |
| Producedin | Sheep |
| Purity | Wholeserum |
| Applications | IHC.Adilutionof1:3000to1:8000isrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Knowntobespecificforbetasynuclein. |
| Cross-reactivity | Thisantiserumisknowtoreactwithhuman,ratandotherrodentbetasynuclein. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| References | 1.Lundvig,etalBrainResMolBrainRes134,3-17(Mar24,2005). 2.Bennett,PharmacolTher105,311-31(Mar,2005). 3.Vekrellis,etal.,MolNeurobiol30,1-21(Aug,2004). 4.Martin,etal.,ProteinPeptLett11,229-37(Jun,2004). 5.Doherty,etal.,ActaNeuropathol(Berl)107,169-75(Feb,2004). 6.Goedert,CurrOpinGenetDev11,343-51(Jun,2001). 7.Saito,etal.,JNeurolSci177,48-59(Aug1,2000). 8.Luckingetal.CellMolLifeSci.2000Dec;57(13-14):1894-908. 9.Kahle,etal.,AnnNYAcadSci920,33-41(2000). 10.Clayton,etal.,TrendsNeurosci21,249-54(Jun,1998). |
