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蚂蚁淘在线 / 品牌中心 / Biosensis / Biosensis/Sheep antibody to alpha synuclein (116-131): affinity purified/S-075-50/50 µg
商品描述
| Description | Alphasynucleinisanabundant140aminoacidneuronalprotein,expressedprimarilyatpresynapticterminalsinthecentralnervoussystem.Alphasynucleinhasbeenassociatedwithseveralneurodegenerativediseases.Apointmutationinthegenecodingforthealpha-synucleinproteinwasthefirstdiscoverylinkingthisproteintoararefamilialformofParkinson"sdisease(PD).Subsequently,othermutationsinthealpha-synucleingenehavebeenidentifiedinfamilialPD.TheaggregatedproteinaceousinclusionscalledLewybodiesfoundinPDandcorticalLewybodydementia(LBD)werediscoveredtobepredominantlyalpha-synuclein.Aberrantaggregationofalpha-synucleinhasbeendetectedinanincreasingnumberofneurodegenerativediseases,collectivelyknownassynucleopathies.Alpha-synucleinexistsphysiologicallyinbothsolubleandmembrane-boundstates,inunstructuredandalpha-helicalconformations,respectively.Thephysiologicalfunctionofalpha-synucleinappearstorequireitstranslocationbetweenthesesubcellularcompartmentsandinterconversionbetweenthe2conformations.Abnormalprocessingofalpha-synucleinispredictedtoleadtopathologicalchangesinitsbindingpropertiesandfunction. |
| BatchNo. | Seeproductlabel |
| Unitsize | 50µg |
| Antigen | Asyntheticpeptide(CMPVDPDNEAYEMPSEE)ofhumanalphasynucleinprotein(aa:116-131)conjugatedtodiphtheriatoxoidhasbeenusedastheimmunogen. |
| OtherNames | Non-AbetacomponentofADamyloid;Non-A4componentofamyloidprecursor;NACP |
| Accession | SYUA_HUMAN |
| Producedin | Sheep |
| Purity | Affinitypurifiedanddialysedagainstphosphatebufferedsaline(PBS).Contains0.02%sodiumazide. |
| Applications | IHC,WB,ELISA.Recommendedtobeusedataconcentrationof1µg/mlforimmunohistochemistry(Paraffinsections);0.5µg/mlforWBandimmunoblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| Specificity | Thisantiserumspecificallydetectsalphasynuclein. |
| Cross-reactivity | Thisantibodyisknowntoreactwithalphasynucleinofhuman,mouse,ratandotherrodents. |
| Blastit | Ifyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis. |
| Form | Lyophilised |
| Reconstitution | Reconstitutein50µlofsterilewater.Centrifugetoremoveanyinsolublematerial. |
| Storage | Afterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles. |
| ExpiryDate | 12monthsafterpurchase |
| SpecificReferences | 1.KuoY.M.etal.(2010)ExtensiveentericnervoussystemabnormalitiesinmicetransgenicforartificialchromosomescontainingParkinsondisease-associatedalpha-synucleingenemutationsprecedecentralnervoussystemchanges.HumMolGenet.May1;19(9):1633-50 2.PelkonenA.etal.(2010)Stimulateddopamineoverflowandalpha-synucleinexpressioninthenucleusaccumbenscoredistinguishratsbredfordifferentialethanolpreference.JNeuRochem.2010Aug;114(4):1168-76. 3.Alvesetal.(2008)StriatalandnigralpathologyinalentiviralratmodelofMachado-JosephdiseaseHumMolGenet.2008Jul15;17(14):2071-83. |
| References | 1.Lundvigetal,BrainResMolBrainRes134,3-17(Mar24,2005). 2.Bennett,PharmacolTher105,311-31(Mar,2005). 3.Vekrellis,etal.,MolNeurobiol30,1-21(Aug,2004). 4.Martin,etal.,ProteinPeptLett11,229-37(Jun,2004). 5.Doherty,etal.,ActaNeuropathol(Berl)107,169-75(Feb,2004). 6.Goedert,CurrOpinGenetDev11,343-51(Jun,2001). 7.Saito,etal.,JNeurolSci177,48-59(Aug1,2000). 8.LückingC.B.etal.,CellMolLifeSci.2000Dec;57(13-14):1894-908. 9.Kahle,etal.,AnnNYAcadSci920,33-41(2000). 10.Clayton,etal.,TrendsNeurosci21,249-54(Jun,1998). |
