Description:
HumanDermalFibroblastsisolatedfromapatientclinicallydiagnosedwithHuntington"sDisease.Inthesecells,onealleleofthehuntingtingene(HTT)hasanexpansionof56CAGrepeatsandtheotherallelehas15CAGrepeats.
Huntington"sDisease
Huntington"sDiseaseisaneurodegenerativedisorderthataffectsmotorfunctionandco-ordinationandprogressivelyleadstodementiainthelaterstagesofthedisease.Followinganautosomaldominantinheritancepattern,Huntington"sDiseaseischaracterizedbyCytosine-Adenine-Guanine(CAG)repeatswithinthehuntingtingene.Anabnormalformofthehuntingtinproteinisproducedthataffectsthefunctionandhealthofneurons.
TheDermalFibroblastscanbereADIlyculturedintheircurrentstateorreprogrammedtoinducedPluripotentStemCells(iPSCs)andderivedtoavarietyofothercelltypes.AlternativelyyoucanpurchaseHumaniPSC-DerivedNeuralStemCells-Huntington"sDiseasePatient(CAG:56)|ax0212readymade!
HereatAxolBiosciencewecanofferaReprogrammingandDifferentiationservice,aspartofourCustomProjects.WecanprovideyouwithavarietyofcellsthathavebeenderivedfromtheseDermalFibroblasts(Huntington"sDisease)toassistwithyourresearch.
AllofthecellsprovidedaretestedandarenegativeforHIV-1,HIV-2,HepatitisBandHepatitisCasdetectedbyPCR.
Thecellsareconfirmedtobenegativeformycoplasmaandotherdetectablemicrobialcontamination.
ProductSpecification:
| Donorgender | Pleaseinquire |
| Donorageatsampling | Pleaseinquire |
| Geneticmodification | None |
| Size | 500,000cells |
| Growthproperties | Adherent |
| Mutation | Onealleleofthehuntingtingene(HTT)hasanexpansionof56CAGrepeatsandtheotherallelehas15CAGrepeats. |
| Shippingconditions | Dryice |
| Storageconditions | Liquidnitrogen |
