Fab-ZAP uses your primary mouse monoclonal IgG antibody to target and eliminate cells that recognize your primary antibody. Fab-ZAP is made with a monovalent secondary antibody eliminating the possibility of cap formation, while preserving all the qualities that make an effective in vitro diagnostic tool. The antibodies used are affinity-purified polyclonal antibodies against both the heavy and light chain of mouse IgG. The antibody used in this product will cross-react across immunoglobulin classes and subclasses of the same species as they share the same light chain (either kappa or lambda). It also has an improved EC50 when directly compared to Mab-ZAP in a cytotoxicity assay.

Fab-ZAP uses your mouse primary antibody to target and eliminate cells. This secondary conjugate is used to evaluate the potential of a primary antibody to internalize.

To view protocol(s) for this and other products please visit: www.ATSbio.com/support/protocols

Advanced Targeting Solutions（ATS）是一家位于圣地亚哥的生物技术公司，致力于为科学研究和药物开发提供高质量的靶向试剂。ATS被称为“萨波林人”，最初致力于为神经科学研究界提供研究工具。多年来，这些工具已用于科学研究和药物开发的所有领域。公司目前的产品线包括针对性毒素，抗体和定制服务，旨在帮助科学家研究系统功能，细胞功能，疾病和病症。ATS率先将靶向结合物用于“分子手术”技术。这些产品包括针对胆碱能性前脑神经元，去甲肾上腺素能和肾上腺素能神经元，巨噬细胞和小胶质细胞的特定损伤剂，以及能侵袭所有神经元上表达的抗原决定簇的泛神经元剂。此外，ATS还出售“次级结合物”，使用户可以将自己的靶向剂转化为特定的细胞毒性工具，并筛选抗体进行内在化。ATS已商业化，并提供了由Douglas Lappi博士开发和完善的Saporin技术平台的访问权限。拉皮博士与医学博士Ronald Wiley合作。在他们的学术实验室中，以验证使用主要的皂素结合物192-IgG-SAP来建立阿尔茨海默氏病模型。丹妮丝·希金斯（Denise Higgins）将她的业务专长和国际销售/营销经验带到了团队中，并将继续致力于将这一创新技术带给全球科学家。