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蚂蚁淘在线 / 品牌中心 / Absolute Antibody / absoluteantibody/Ab00718-10.3 Anti-TNF alpha [D2E7 (Adalimumab)]/Ab00718-10.3/200 µg
商品描述
Description:RecombinantmonoclonalantibodytoTNFalpha.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthetherapeuticantibodyD2E7(Adalimumab).ThisantibodywascreatedusingourproprietaryFcSilent™engineeredFcdomaincontainingkeypointmutationsthatabrogatebindingtoFcgammareceptors.
CloneNumber:D2E7(Adalimumab)
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):block;ELISA;IHC;IF
PublishedSpeciesReactivity:Human
Immunogen:Thisantibodywasgeneratedbyaffinitymaturationfromthe2SD4scFv,whichinturnwasselectedonhumanTNFalphabyguidedphage-displaytechnology,usingthemurineanti-hTNFalphaantibodyMab32asatemplate(c.f.alsoUSPatent6090382).
Specificity:BindstosolubleTNF-alpha,butnottolymphotoxin(TNFbeta).
ApplicationNotes:AdalimumabbindsspecificallytoTNFandneutralizestheBIOLOGicalfunctionofTNFbyblockingitsinteractionwiththep55andp75cellsurfaceTNFreceptors.
AntibodyFirstPublishedin:
Jespersetal.Guidingtheselectionofhumanantibodiesfromphagedisplayrepertoirestoasingleepitopeofanantigen.NatureBiotechnology12,899-903(1994)PMID:7521646Noteonpublication:Describesthegenerationofthisantibodybyguidedphage-display.
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals. Absolute Antibody我们现在与Digital Proteomics合作提供多克隆永生化服务。这意味着您可以生产可复制且不受限制的多克隆试剂，或者利用天然免疫系统来识别新的抗体候选物。对于这项服务，您可以提供免疫宿主生物的血清和B细胞，纯化的抗原用于免疫，或者只是告诉我们您的靶标，我们将做剩下的事情。鉴于其中之一，我们可以提供多达10条由发现引擎选择的重链序列和10条轻链序列，在交互式报告中提供具有蛋白质组学证据的扩展库，根据要求将抗体工程化为任何种类和同种型，以及我们提供的抗体表征数据获得。此服务是100％免版税的。 NOTFORTHERAPEUTICUSE-Thisisaresearch-gradebiosimilar.
SpeciesandIsotype:HumanIgG1,FcSilent™,kappaCloneNumber:D2E7(Adalimumab)
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):block;ELISA;IHC;IF
PublishedSpeciesReactivity:Human
Immunogen:Thisantibodywasgeneratedbyaffinitymaturationfromthe2SD4scFv,whichinturnwasselectedonhumanTNFalphabyguidedphage-displaytechnology,usingthemurineanti-hTNFalphaantibodyMab32asatemplate(c.f.alsoUSPatent6090382).
Specificity:BindstosolubleTNF-alpha,butnottolymphotoxin(TNFbeta).
ApplicationNotes:AdalimumabbindsspecificallytoTNFandneutralizestheBIOLOGicalfunctionofTNFbyblockingitsinteractionwiththep55andp75cellsurfaceTNFreceptors.
AntibodyFirstPublishedin:
Jespersetal.Guidingtheselectionofhumanantibodiesfromphagedisplayrepertoirestoasingleepitopeofanantigen.NatureBiotechnology12,899-903(1994)PMID:7521646Noteonpublication:Describesthegenerationofthisantibodybyguidedphage-display.
ProductForm
Purification:ProteinAaffinitypurifiedSuppliedin:PBSwith0.02%Proclin300.
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°CConcentration:Seeviallabel.
