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蚂蚁淘在线 / 品牌中心 / Absolute Antibody / absoluteantibody/Ab00906-10.3 Anti-ZIKV soluble envelope protein [z23]/Ab00906-10.3/ 200 µg
商品描述
Description:RecombinantmonoclonalantibodytoZIKVsolubleenvelopeprotein.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehybridomaz23.ThisantibodywascreatedusingourproprietaryFcSilent™engineeredFcdomaincontainingkeypointmutationsthatabrogatebindingtoFcgammareceptors.
SpeciesandIsotype:HumanIgG1,FcSilent™,kappa
CloneNumber:z23
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):Block
PublishedSpeciesReactivity:Zikavirus
Immunogen:ThisantibodywasderivedfrommemoryBcellsspecificforpurifiedmonomericZikavirussolubleenvelopeprotein,whichwereisolatedbyFACSfromthebloodofapatient20dayspost-infectionwithzikavirus.Togeneratefull-lengthmonoclonalantibodies,thevariableregionswerethenclonedintohumanIgG1constantregion.
Specificity:ThisantibodybindatertiaryepitopeinthezikavirussolubleenvelopeproteindomainIII.
ApplicationNotes:ThisantibodyspecificallyandpotentlyneutralisesZikavirusinvitro,anddoesnotcross-reactwithstrains1-4ofdenguevirus,whichminimisestheriskofantibody-dependentenhancement(Wangetal,2016).Inamurinemodel,thisantibodyconferspostexposureprotectionagainstZikavirus(Wangetal,2016).
AntibodyFirstPublishedin:
Wangetal.MoleculardeterminantsofhumanneutralizingantibodiesisolatedfromapatientinfectedwithZikavirusScienceTranslationalMedicine,December14,2016,Vol.8(369),p.369ra179Noteonpublication:Describestheoriginalgenerationandcharacterisationofthisantibody.
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals. Absolute Antibody我们现在与Digital Proteomics合作提供多克隆永生化服务。这意味着您可以生产可复制且不受限制的多克隆试剂，或者利用天然免疫系统来识别新的抗体候选物。对于这项服务，您可以提供免疫宿主生物的血清和B细胞，纯化的抗原用于免疫，或者只是告诉我们您的靶标，我们将做剩下的事情。鉴于其中之一，我们可以提供多达10条由发现引擎选择的重链序列和10条轻链序列，在交互式报告中提供具有蛋白质组学证据的扩展库，根据要求将抗体工程化为任何种类和同种型，以及我们提供的抗体表征数据获得。此服务是100％免版税的。 SpeciesandIsotype:HumanIgG1,FcSilent™,kappa
CloneNumber:z23
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):Block
PublishedSpeciesReactivity:Zikavirus
Immunogen:ThisantibodywasderivedfrommemoryBcellsspecificforpurifiedmonomericZikavirussolubleenvelopeprotein,whichwereisolatedbyFACSfromthebloodofapatient20dayspost-infectionwithzikavirus.Togeneratefull-lengthmonoclonalantibodies,thevariableregionswerethenclonedintohumanIgG1constantregion.
Specificity:ThisantibodybindatertiaryepitopeinthezikavirussolubleenvelopeproteindomainIII.
ApplicationNotes:ThisantibodyspecificallyandpotentlyneutralisesZikavirusinvitro,anddoesnotcross-reactwithstrains1-4ofdenguevirus,whichminimisestheriskofantibody-dependentenhancement(Wangetal,2016).Inamurinemodel,thisantibodyconferspostexposureprotectionagainstZikavirus(Wangetal,2016).
AntibodyFirstPublishedin:
Wangetal.MoleculardeterminantsofhumanneutralizingantibodiesisolatedfromapatientinfectedwithZikavirusScienceTranslationalMedicine,December14,2016,Vol.8(369),p.369ra179Noteonpublication:Describestheoriginalgenerationandcharacterisationofthisantibody.
ProductForm
Purification:ProteinAaffinitypurifiedSuppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
