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蚂蚁淘在线 / 品牌中心 / Absolute Antibody / absoluteantibody/Ab00772-10.3 Anti-Glycoprotein H [A13-d6.3]/Ab00772-10.3/ 200 µg
商品描述
Description:RecombinantmonoclonalantibodytoGlycoproteinH.ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromthehyBDridomaA13-d6.3.ThisantibodywascreatedusingourproprietaryFcSilent™engineeredFcdomaincontainingkeypointmutationsthatabrogatebindingtoFcgammareceptors.
CloneNumber:A13-d6.3
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):neutralize;crystalize;immunostaining
PublishedSpeciesReactivity:pseudorABIesvirus(PrV)
Immunogen:d6.3wasgeneratedbyimmunizingmicewithPrV.
Specificity:d6.3FabfragmentbindstothecorefragmentofthePrVglycoproteinH(gH)ectodomain(aa107–639)whichisthemembrane-proximalendoftheproteininthe?gL-PassPrVvariantofPrV.Theantibodycontactsresidues332-373(peripheralhelicesα6andα7ofdomainIIIofgHcontributemostoftheresiduesthatformtheepitoperecognizedbyd6.3).PrVisaporcineherpesvirusbelongingtothealpha-HerpesvirinaesubfamilyandisknowntocauseAukeszky"sdiseaseinpigs.gHisatypeImembraneporteinandcaninteractnon-covalentlywithgLviathelargegHectodomain.
ApplicationNotes:d6.3 neutralizesthe?gL-PassPrVvariantofPrVandcanstain?gL-PassPrVvariantbutnotthewild-typePrVbyimmunostaining.Theepitopeofd6.3isnotblockedbytheformationofthegH/gLheterodimer.Thed6.3Fabfragmnet(obtainedthroughpapaindigestion)canbecomplexedwiththecorefragmentofthePrVglycoproteinH(gH)ectodomain(aa107–639)forstructuralstudiesbycrystallography.
AntibodyFirstPublishedin:
Backovicetal.StructureofacorefragmentofglycoproteinHfrompseudorabiesvirusincomplexwithantibody.ProcNatlAcadSciUSA. 2010Dec28;107(52):22635-40PMID:21149698Noteonpublication:DescribesthedeterminationofthecrystalstructureofPrVgHcomplexedwithd6.3andthemodeofantibodybinding.ThesolvedstructureisalsousedtocomparePrVgHwiththatofEpstein-Barrvirus(EBV).
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals. Absolute Antibody我们现在与Digital Proteomics合作提供多克隆永生化服务。这意味着您可以生产可复制且不受限制的多克隆试剂，或者利用天然免疫系统来识别新的抗体候选物。对于这项服务，您可以提供免疫宿主生物的血清和B细胞，纯化的抗原用于免疫，或者只是告诉我们您的靶标，我们将做剩下的事情。鉴于其中之一，我们可以提供多达10条由发现引擎选择的重链序列和10条轻链序列，在交互式报告中提供具有蛋白质组学证据的扩展库，根据要求将抗体工程化为任何种类和同种型，以及我们提供的抗体表征数据获得。此服务是100％免版税的。 ThischimerichumanantibodywasmadeusingthevariabledomainsequencesoftheoriginalMouseIgG2bformat,forimprovedcompatibilitywithexistingreagents,assaysandtechniques.
SpeciesandIsotype:HumanIgG1,FcSilent™,kappaCloneNumber:A13-d6.3
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):neutralize;crystalize;immunostaining
PublishedSpeciesReactivity:pseudorABIesvirus(PrV)
Immunogen:d6.3wasgeneratedbyimmunizingmicewithPrV.
Specificity:d6.3FabfragmentbindstothecorefragmentofthePrVglycoproteinH(gH)ectodomain(aa107–639)whichisthemembrane-proximalendoftheproteininthe?gL-PassPrVvariantofPrV.Theantibodycontactsresidues332-373(peripheralhelicesα6andα7ofdomainIIIofgHcontributemostoftheresiduesthatformtheepitoperecognizedbyd6.3).PrVisaporcineherpesvirusbelongingtothealpha-HerpesvirinaesubfamilyandisknowntocauseAukeszky"sdiseaseinpigs.gHisatypeImembraneporteinandcaninteractnon-covalentlywithgLviathelargegHectodomain.
ApplicationNotes:d6.3 neutralizesthe?gL-PassPrVvariantofPrVandcanstain?gL-PassPrVvariantbutnotthewild-typePrVbyimmunostaining.Theepitopeofd6.3isnotblockedbytheformationofthegH/gLheterodimer.Thed6.3Fabfragmnet(obtainedthroughpapaindigestion)canbecomplexedwiththecorefragmentofthePrVglycoproteinH(gH)ectodomain(aa107–639)forstructuralstudiesbycrystallography.
AntibodyFirstPublishedin:
Backovicetal.StructureofacorefragmentofglycoproteinHfrompseudorabiesvirusincomplexwithantibody.ProcNatlAcadSciUSA. 2010Dec28;107(52):22635-40PMID:21149698Noteonpublication:DescribesthedeterminationofthecrystalstructureofPrVgHcomplexedwithd6.3andthemodeofantibodybinding.ThesolvedstructureisalsousedtocomparePrVgHwiththatofEpstein-Barrvirus(EBV).
ProductForm
Purification:ProteinAaffinitypurifiedSuppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
