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蚂蚁淘在线 / 品牌中心 / Absolute Antibody / absoluteantibody/Ab00940-10.0 Anti-Envelope protein (soluble) [Z3L1]/Ab00940-10.0/ 200 µg
商品描述
Description:RecombinantmonoclonalantibodytoEnvelopeprotein(soluble).ManufacturedusingAbAb’sRecombinantPlatformwithvariableregions(i.e.specificity)fromtheB-cellcloneZ3L1.
SpeciesandIsotype:HumanIgG1,lamBDa
CloneNumber:Z3L1
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):NTRL;crystallisation;ELISA;FC;SPR
PublishedSpeciesReactivity:Zikavirus
Immunogen:Anti-ZIKVmAbswereobtainedfromtheseraandperipheralbloodmononuclearcellsofaZIKV-infectedpatient.
Specificity:Z3L1bindstotheZIKVsolubleenvelope(sE)protein,shownusingSPR,kineticcompetitionassaysandcrystallography(Wangetal,2016).ThismAbishighlyspecificforZIKV,andwasshowntoexhibitnoneutralisationactivityagainstDENV-1toDENV-4virions,whicharehighlyrelatedtoZIKV.ItwasshowncrystallographicallythattheZ3L1FabregionbindstodomainIanddomainIIofsE.ZIKVhasrecentlybecomeamajorglobalhealthconcern,followinga2015outbreak.Viralinfectionisassociatedwithneurologicalcomplicationsandmicroencephaly.
ApplicationNotes:Z3L1wasconfirmedtobindZIKVsEproteinbyELISA,withanaffinityof5.39uMshownbySPR(Wangetal,2016).UsingaFACS-basedassay,itwasshownthatZ3L1wassufficientforcompleteneutralisationofviralactivityagainstinfectedC6/36andVerocells.Invivo,ithasbeenshownthatZ3L1protectedIFNreceptorKOmicefromZIKVinfection.
AntibodyFirstPublishedin:
Wangetal.MoleculardeterminantsofhumanneutralizingantibodiesisolatedfromapatientinfectedwithZikavirus.SciTranslMed.2016Dec14;8(369):369ra179.Noteonpublication:Describestheidentificationofseveralanti-ZIKVmAbsfromthebloodofapatientwithZIKVinfection.ThemAbsidentifiedwerecharacterisedforantigenspecificityusingbiochemicalandbiophysicalmethods,andafewofthemAbsfoundwerecrystallisedwiththeZIKVsEprotein.
Suppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
Importantnote–Thisproductisforresearchuseonly.Itisnotintendedforuseintherapeuticordiagnosticproceduresforhumansoranimals. Absolute Antibody我们现在与Digital Proteomics合作提供多克隆永生化服务。这意味着您可以生产可复制且不受限制的多克隆试剂，或者利用天然免疫系统来识别新的抗体候选物。对于这项服务，您可以提供免疫宿主生物的血清和B细胞，纯化的抗原用于免疫，或者只是告诉我们您的靶标，我们将做剩下的事情。鉴于其中之一，我们可以提供多达10条由发现引擎选择的重链序列和10条轻链序列，在交互式报告中提供具有蛋白质组学证据的扩展库，根据要求将抗体工程化为任何种类和同种型，以及我们提供的抗体表征数据获得。此服务是100％免版税的。 SpeciesandIsotype:HumanIgG1,lamBDa
CloneNumber:Z3L1
UniProtAccessionNumberofTargetProtein:
PublishedApplication(s):NTRL;crystallisation;ELISA;FC;SPR
PublishedSpeciesReactivity:Zikavirus
Immunogen:Anti-ZIKVmAbswereobtainedfromtheseraandperipheralbloodmononuclearcellsofaZIKV-infectedpatient.
Specificity:Z3L1bindstotheZIKVsolubleenvelope(sE)protein,shownusingSPR,kineticcompetitionassaysandcrystallography(Wangetal,2016).ThismAbishighlyspecificforZIKV,andwasshowntoexhibitnoneutralisationactivityagainstDENV-1toDENV-4virions,whicharehighlyrelatedtoZIKV.ItwasshowncrystallographicallythattheZ3L1FabregionbindstodomainIanddomainIIofsE.ZIKVhasrecentlybecomeamajorglobalhealthconcern,followinga2015outbreak.Viralinfectionisassociatedwithneurologicalcomplicationsandmicroencephaly.
ApplicationNotes:Z3L1wasconfirmedtobindZIKVsEproteinbyELISA,withanaffinityof5.39uMshownbySPR(Wangetal,2016).UsingaFACS-basedassay,itwasshownthatZ3L1wassufficientforcompleteneutralisationofviralactivityagainstinfectedC6/36andVerocells.Invivo,ithasbeenshownthatZ3L1protectedIFNreceptorKOmicefromZIKVinfection.
AntibodyFirstPublishedin:
Wangetal.MoleculardeterminantsofhumanneutralizingantibodiesisolatedfromapatientinfectedwithZikavirus.SciTranslMed.2016Dec14;8(369):369ra179.Noteonpublication:Describestheidentificationofseveralanti-ZIKVmAbsfromthebloodofapatientwithZIKVinfection.ThemAbsidentifiedwerecharacterisedforantigenspecificityusingbiochemicalandbiophysicalmethods,andafewofthemAbsfoundwerecrystallisedwiththeZIKVsEprotein.
ProductForm
Purification:ProteinAaffinitypurifiedSuppliedin:PBSwithpreservative(0.02%Proclin300)
StorageRecommendation:Storeat4°Cforupto3months.Forlongertermstoragealiquotintosmallvolumesandstoreat-20°C
Concentration:Seeviallabel.
