Overview

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Ex/Em(nm)	351/430
MW	324.80
CAS#	62480-44-8
Solvent	DMSO
Storage	F/D/L
Category	EnzymeDetection PeptidasesandProteases
Related

Leu-AMCisafluorogenicsubstrateforleucineaminopeptidase.Uponthehydrolysisbyproteases,Leu-AMCreleasesthestronglyfluorescentAMCfluorophorethatcanbereADIlydetectedwithEx/Em=350/430nm.

Spectrum

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References&Citations

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1. WangKD,WangKH,ZhouND,TianYP.(2016)SecretoryExpression,Purification,Characterization,andApplicationofanAspergillusoryzaeProlylAminopeptidaseinBacillussubtilis.ApplBiochemBiotechnol.
2. MunkhjargalT,IshizakiT,GuSwantoA,TakemaeH,YokoyamaN,IgarashiI.(2016)MolecularandbiochemicalcharacterizationofmethionineaminopeptidaseofBabesiabovisasapotentdrugtarget.VetParasitol,221,14.
3. WangX,ShiL,DengY,QuM,MaoS,XuL,XuW,FangC.(2015)Inhibitionofleucineaminopeptidase3suppressesinvasionofovariancancercellsthroughdown-regulationoffascinandMMP-2/9.EurJPharmacol,768,116.
4. LeeYR,NaBK,MoonEK,SongSM,JooSY,KongHH,GooYK,ChungDI,HongY.(2015)EssentialRoleforanM17LeucineAminopeptidaseinEncystationofAcanthamoebacastellanii.PLoSOne,10,e0129884.
5. AbogeGO,CaoS,TerkawiMA,MasataniT,GooY,AbouLailaM,NishikawaY,IgarashiI,SuzukiH,XuanX.(2015)MolecularCharacterizationofBabesiabovisM17LeucineAminopeptidaseandInhibitionofBabesiaGrowthbyBestatin.JParasitol,101,536.
6. SahiS,RajU,ChaudharyM,NainV.(2014)ModellingofhumanleucylaminopeptidasesforinsilicoofftargetbindinganalysisofpotentialPlasmodiumfalciparumleucineaminopeptidase(PfA-M17)specificinhibitors.RecentPatEndocrMetabImmuneDrugDiscov,8,191.
7. LiewSM,TayST,PuthuchearySD.(2013)EnzymaticandmolecularcharacterisationofleucineaminopeptidaseofBurkholderiapseudomallei.BMCMicrobiol,13,110.
8. MaC,JinK,CaoJ,ZhangL,LiX,XuW.(2013)NovelleucineureidoderivativesasinhibitorsofaminopeptidaseN(APN).BioorgMedChem,21,1621.
9. HalderAK,SahaA,JhaT.(2013)ExplorationofstructuralandphysicochemicalrequirementsandsearchofvirtualhitsforaminopeptidaseNinhibitors.MolDivers,17,123.
10. CarrollRK,VeillardF,GagneDT,LindenmuthJM,PorebaM,DragM,PotempaJ,ShawLN.(2013)TheStaphylococcusaureusleucineaminopeptidaseislocalizedtothebacterialcytosolanddemonstratesabroadsubstraterangethatextendsbeyondleucine.BiolChem,394,791.

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