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蚂蚁淘在线 / 品牌中心 / BPS Bioscience / Bpsbioscience/Human/Mouse ERK2 (K52R), Inactive, His-tag/40056/100 µg
商品描述
Species: Mouse
Host Species: E. coli
MW: 42 kDa
Genbank #: NM_0011949
Tag(s): N-terminal His-tag
a.a: full length
Description:
Human/Mouse ERK2/MAPK2 (K52R) (GenBank Accession No. NM_0011949), full length with mutation on lysine52 to arginine and with an N-terminal His-tag, MW=42 kDa, expressed in E. coli . The K52R mutation prevents ATP binding, making the kinase inactive.
Synonym(s):
ERK2, MAPK1, mitogen-activated protein kinase 1, Extracellular Signal-Regulated Kinase 2, PRKM
Specific Activity:
inactive
Formulation:
45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 125 mM imidazole, 3 mM DTT, 10% glycerol.
Format:
Aqueous buffer solution
Storage / Stability:
>6 months at -80°C.
Application(s):
Useful as a substrate for MEK1.
Reference(s):
1. Robinson, M.J., et al. Biochemistry. 1996 May 7;35(18):5641-6.
2. Mitsushima, M. et al. Cell Res. 313 (9), 1830- 1838 (2007).
3. Wille, L. et al. Mol. Immunol. 44 (12), 3085- 3091 (2007).
Application Reference(s):
1. BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity (2017)
Notes:
The human and mouse versions of this protein share 100% amino acid homology.
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Kinase/Substrate
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
