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商品描述
Species:Human
HostSpecies:E.coli
MW:60kDa
Genbank#:NM_005057
Tag(s):N-terminalHis-tag
a.a:2–538(end)
Background:
RbBP5bindsdirectlytoretinoblastomaprotein,whichregulatescellproliferation.ItinteractspreferentiallywiththeunderphosphorylatedretinoblastomaproteinviatheE1A-bindingpocketB.Inembryonicstem(ES)cells,RbBP5playsacrucialroleinthedifferentiationpotential,particularlyalongtheneurallineage,regulatinggeneinductionandH3Lys4methylationatkeydevelopmentalloci,includingthatmediatedbyretinoicacid.AspartoftheMLL1/MLLcomplex,involvedinmono-,di-andtrimethylationatLys4ofhistoneH3.
Description:
Humanretinoblastomabindingprotein5(RbBP5),GenBankAccessionNo.NM_005057,a.a.2–538(end)withN-terminalHis-tag,MW=60kDa,expressedinanE.coliexpressionsystem.
UniProt
Q15291
Synonym(s):
Rbbp5,retinoblastomabindingprotein5,Set1cWD40RepeatProtein,SWD1,RBQ3
Formulation:
20mMTris-HCl,pH7.4,300mMNaCl,10%glycerol,1mMTCEP,and1µMZnCl2
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C
Application(s):
Usefulforthestudyofenzymekinetics,screeninginhibitors,andselectivityprofiling.
Reference(s):
1.Cao,F.,etal.,PLoSOne.2012Nov23;5(11):e14102.
2.Odho,Z.,etal.,JBiolChem.2010Oct22;285(43):32967-76.
2.Odho,Z.,etal.,JBiolChem.2010Oct22;285(43):32967-76.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Miscellaneous
ProductType:
RecombinantProtein
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