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商品描述
MW:224.2Da
CASRegistry#:67200-34-4
Formula:C11H4N4O2S
Description:
SmallMoleculeEnhancerofRapamycin3(SMER3)isaspecificinhibitoroftheubiquitinE3ligaseSCFMET30.SMER3bindsdirectlytotheF-boxsubunitMet30andblocksbindingtotheSCFcorecomplex.Cellpermeable.Significantinhibitionistypicallyseenat30-100μM.
Synonym(s):
9H–Indeno[1,2–e][1,2,5]oxADIazolo[3,4–b]pyrazin–9–one
Purity:
>98%byTLC.
Solubility:
SolubleinDMSO(upto20mg/ml,withheating)
Format:
Yellowpowder
Storage/StABIlity:
Storeat+4°C.Stableassuppliedforupto2yearswhenstoreddessicatedat+4°C.Storesolutionsat-20°Cforupto2months.
Application(s):
UsefulfortheinhibitionofSCFMET30incell-basedorinvitroassays.
Reference(s):
1.Aghajanyy,M.etal.ChemicalgeneticsofTORidentifiesanSCFfamilyE3ubiquitinligaseinhibitor.Nat.Biotech.2010,28(7):738.
Warning(s):
Protectfrommoisture.
ScientificCategory:
UbiquitinEnzymes
ProductType:
Inhibitors/Activators
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