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商品描述
Species: Human
Host Species: FreeStyle 293-F cells
MW: 53 kDa
Genbank #: NM_005040
Tag(s): C-terminal His-tag
a.a: 31–496
Background:
PrCP is a lysosomal prolylcarboxypeptidase that cleaves C-terminal amino acids linked to proline. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. PrCPs role in angiotension II cleavage, which regulates blood pressure and electrolyte balance, suggests that PrCP may be involved in hypertension.
Description:
Human recombinant Lysosomal Pro-X carboxypeptidase, also known as angiotensinase C (GenBank Accession #NM_005040), a.a. 31-496 with C-terminal His-tag, MW=53 kDa, expressed in HEK293 cells.
UniProt
P42785
Synonym(s):
Proline Carboxypeptidase, Angiotensinase C, PCP, Lysosomal Pro-X carboxypeptidase
Formulation:
40 mM Tris pH 8.0, 110 mM NaCl, 2.2 mM KCl, 20% glycerol, 3 mM DTT, 200 mM imidazole
Format:
Aqueous buffer solution
Storage / Stability:
Stable at least 6 months from date of receipt, when stored as directed
Application(s):
Useful for the cleavage of C-terminal amino acids linked to proline in peptides, for example, angiotension II, III and des-Arg9-bradykinin.
Reference(s):
1. Tan, F., et al. 1993. J Biol Chem 268 (22): 16631–8.
2. Yang, H.Y., et al. 1968. Nature 218 (5148): 1224–6.
3. Wang, L., et al. 2006. Am. J. Obstet. Gynecol. 195 (1): 162–71.
2. Yang, H.Y., et al. 1968. Nature 218 (5148): 1224–6.
3. Wang, L., et al. 2006. Am. J. Obstet. Gynecol. 195 (1): 162–71.
Warning(s):
Avoid freeze/thaw cycles
Scientific Category:
Protease
Product Type:
Recombinant Protein
Data shown is lot-specific. Contact us for specific information on other lots.
