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商品描述
MW: 315.8 Da
CAS Registry #: 175178-82-2
Formula: C16H14ClN3O2
Description:
Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Much weaker inhibitor of PDGF receptor and HER2-NEU kinases (IC50 >100 µM). Reversibly inhibits (IC50 = 9.8 µM) the rat brain Kv1.5 potassium channel in vitro in a non-protein-tyrosine-kinase-mediated manner.
Synonym(s):
AG 1478
Purity:
≥99%
Solubility:
Soluble in DMSO at 50 mg/ml; soluble in ethanol at 25 mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Format:
A white solid
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
1. Osherov, N. and Levitzki, A. Eur. J. Biochem. 225: 1047-1053 (1994).
2. Levitzki, A. and Gazit, A. Science 267: 1782-1788 (1995).
3. Choi, B.H., et al. Am. J. Physiol. Cell Physiol. 282: C1461-C1468 (2002).
2. Levitzki, A. and Gazit, A. Science 267: 1782-1788 (1995).
3. Choi, B.H., et al. Am. J. Physiol. Cell Physiol. 282: C1461-C1468 (2002).
Scientific Category:
Kinase
Product Type:
Inhibitor
Data shown is lot-specific. Contact us for specific information on other lots.
