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商品描述
Species:Human
HostSpecies:E.coli
MW:39kDa
Genbank#:NM_002690
Tag(s):N-terminalHis-tag
a.a:2–335(end)
Background:
DNApolymeraseinvolvedinbaseexcisionandrepair.Has5"-deoxyribose-5-phosphatelyase(dRPlyase)activitythatremovesthe5"sugarphosphateandalsoactsasaDNApolymerasethataddsonenucleotidetothe3"endofthearisingsingle-nucleotidegap.Conducts"gap-filling"DNAsynthesisinastepwisedistributivefashionratherthaninaprocessivefashionasforotherDNApolymerases.Theproteinisnormallyfoundinthecytoplasm,butittranslocatestothenucleusuponDNAdamage.
Description:
HumanDNApolymeraseβ(beta),alsoknownasPolbetaandPOLB(GenBankAccessionNo.NM_002690),a.a.2-335(end),withN-terminalHis-tag,MW=39kDa,expressedinanE.colicellexpressionsystem.
Synonym(s):
DNApolymerasebeta,PolbetaandPOLB
Formulation:
40mMTris-HCl,pH8.0,110mMNaCl,2.2mMKCl,250mMimidazole,0.04%Tween-20,and20%glycerol.
Format:
Aqueousbuffersolution
Storage/StABIlity:
>6monthsat-80°C.
Application(s):
UsefulforDNAsynthesisandDNArepair,asanantigenforWesternblotting,andforinhibitorscreening.
Reference(s):
1.Yamtich,J.,etal.,PLoSGenet.2012,8(11):E1003052.
2.Wang,K.,etal.,CancerRes.1992,52(17):4824-4827.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
MolecularBIOLOGy
ProductType:
RecombinantProtein
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