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商品描述
Species:Human
HostSpecies:E.coli
MW:9kDa
Genbank#:O00175
a.a:27–104
Background:
Eotaxinbelongstotheplateletfactor-4familyofchemokines.ThefactorisbeingreferredtoalsoasEotaxin-2andhasbeenrenamedCCL24.Botheotaxin-2/CCL24andeotaxin-3/CCL26areCCchemokinesandfunctionalligandsforCCchemokinereceptor3(CCR3),whichispreferentiallyexpressedoneosinophils.Only34%oftheaminoacidsineotaxin-2/CCL24andeotaxin-3/CCL26areidentical,butthesetwochemokineshaveacommoncharacteristicfeatureintermsofchemotaxisforeosinophilsviatheCCR3.
Description:
RecombinantEotaxin-2isadisulfide-linkedhomodimericproteinconsistingof79aminoacidresidues,andmigratesasanapproximately9kDaproteinundernon-reducingandreducingconditionsinSDS-PAGE.OptimizedDNAsequenceencodinghumanEotaxin-2maturechainwasexpressedinE.coli.
UniProt
O00175
Synonym(s):
CCL24,MPIF2,Eotaxin-2,SCYA24
Purity:
≥97%bySDS-PAGEandHPLC
EndotoxinLevel:
<0.1ng/µg(1EU/µg),usingtheLALgelclotmethod.
Formulation:
Lyophilizedfrom0.2µmfilteredconcentrated(1.0mg/ml)solutionin100mMNaCl,10mMphosphatebuffer,pH7.0.
Format:
lyophilizedprotein
Reconstitution:
Reconstituteat0.1-1.0mg/mlindistilledwater.Thissolutioncanthenbedilutedintootherbuffers.Tomaximizeproductcollectionfromvialsurface,vortexbrieflyandthenspindowntorecollecttheliquid.
Storage/Stability:
Thelyophilizedproteinisstableforatleast2yearsfromdateofreceiptwhenstoredat-20°C.Uponreconstitution,storeinworkingaliquotsat+4°Cforuptoonemonth,orat-20°Cforuptosixmonths,inthepresenceofacarrierprotein.Avoidrepeatedfreeze/thawcycles.
Reference(s):
1.Clin.CancerRes.,Oct2007,13:5719-5728.
2.J.Biol.Chem.,Apr2005,280:13952-13961.
3.J.Immunol.,Sep2002,169:2712-2718.
2.J.Biol.Chem.,Apr2005,280:13952-13961.
3.J.Immunol.,Sep2002,169:2712-2718.
Warning(s):
Avoidfreeze/thawcycles
AminoAcidSequence:
VVIPSPCCMFFVSKRIPENRVVSYQLSSRSTCLKAGVIFTTKKGQQFCGDPKQEWVQRYMKNLDAKQKKASPRARAVA
ScientificCategory:
Cytokine/GrowthFactors
ProductType:
RecombinantProtein
Datashownislot-specific.Contactusforspecificinformationonotherlots.
