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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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0512-67156496
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info@ebiomall.com
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商品描述
HostSpecies:Mouse
Clonality:monoclonal
Background:
HDAC2(UniProt/Swiss–ProtentryQ92769)belongstothefamilyofhistonedeacetylaseswhichcatalysethedeacetylationoflysineresiduesontheN–terminalpartofthecorehistones(H2A,H2B,H3andH4).AcetylationanddeacetylationofthesehighlyconservedlysineresiduesisimportantforthecontrolofgeneexpressionandHDAC2activityisassociatedwithgenerepression.Histonedeacetylationisestablishedbytheformationoflargemultiproteincomplexes.Thereby,HDAC2associateswithmanydifferentproteins,includingthemammalianzinc–fingertranscriptionfactorYY1.HDAC2thusplaysanimportantroleintranscriptionalregulation,cellcycleprogressionanddevelopmentalevents.
Description:
MonoclonalantibodyraisedinmouseagainsthumanHDAC2(Histonedeacetylase2),usingaKLH–conjugatedsyntheticpeptidecontainingasequencefromtheC–terminalregionoftheprotein.
Synonym(s):
HD2,RPD3,YAF1
AssayConditions:
WesternblotanalysisusingthemonoclonalantibodydirectedagainstHDAC2
WholecellextractsfromHeLacells(25μg)wereanalysedbyWesternblotusingthemonoclonalantibodyagainstHDAC2(Cat.No.25288)diluted1:1,000inTBS-Tweencontaining5%skimmedmilk.Thepositionoftheproteinofinterestisindicatedontheright(expectedsize:55kDa);theMarker(inkDa)isshownontheleft.
Concentration:
50µg/25µl
Formulation:
PBScontaining0.05%azideand0.05%ProClin300
SpeciesReactivity:
Human
Purification:
ProteinApurified
Immunogen:
syntheticpeptide
Format:
Aqueousbuffersolution
Storage/StABIlity:
Storeat–80°Cforupto2years.Centrifugeafterfirstthawtomaximizeproductrecovery.Aliquottoavoidrepeatedfreeze/thawcycles.Aliquotsmaybestoredat–20°Cforatleastonemonth.
Application(s):
WB(1:1000)
Notes:
Theoptimalantibodyconcentrationshouldbedeterminedbytheend–user.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Antibodies
ProductType:
Antibody
Datashownislot-specific.Contactusforspecificinformationonotherlots.
