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蚂蚁淘在线 / 品牌中心 / BPS Bioscience / Bpsbioscience/CECR2 Inhibitor Screening Assay Kit/32611/384 reactions
商品描述
Description:
TheCECR2InhibitorScreeningAssayKitisdesignedtomeasuretheinhibitionofCECR2bindingtoitssubstrate.ThekeytotheCECR2InhibitorScreeningAssayKitisthehighlyspecificbindingoftheCECR2bromodomaintotheacetylatedhistonesubstrate.Withthiskit,onlythreesimplestepsonamicrotiterplatearerequired.First,asamplecontainingCECR2andaninhibitorofchoiceisincubatedwiththebiotinylatedsubstrateforthirtyminutes.Next,acceptorbeadsareadded,thendonorbeads,followedbyreADIngtheAlpha-counts.
Synonym(s):
CECR2,cateyesyndromechromosomeregion,candidate2
SuppliedAs:
KitcomesinaconvenientAlphaLISA®format,withbiotinylatedhistonepeptidesubstrate,assaybuffer,detectionbufferandpurifiedCECR2(CatEyeSyndromeChromosomeRegion2)bromodomaintoperformatotalof384enzymereactions.
Contraindications:
OnlylimitedamountsofDMSOcanbeincluded,asithasbeenshowntodisruptBRD-ligandinteraction.AvoidgreenandbluedyesthatabsorblightintheAlphaScreen®signalemissionrange(520-620nm),suchasTrypanBlue.
Format:
COMPONENTS:
Instructionsforuse:
Seedatasheetfordetailedprotocol.
Storage/StABIlity:
Stableatleast12monthsfromdateofreceipt,whenstoredasdirected.Kitcomponentsrequiredifferentstorageconditions.Besuretostoreeachcomponentatthepropertemperatureuponarrival.
Application(s):
Usefulforthestudyofbromodomainbindingassays,screeningbromodomaininhibitorsandselectivityprofiling.
Reference(s):
LeeS-K,etal.,Mol.Cells2012,34(1):85-91.
Warning(s):
Avoidfreeze/thawcycles
ScientificCategory:
Bromodomain
ProductType:
AssayKit
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