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商品描述
MW:263.3Da
CASRegistry#:187389-53-3,634911-80-1
Formula:C11H18FNO5
Target:pan-caspase
Background:
Boc-D-FMKisacell-permeablebroad-spectrumcaspaseinhibitorthatfullyinhibitsthepro-apoptoticeffectoftumornecrosisfactor-α(TNFα)withIC50valueof39µM.Boc-D-FMKhasbeenfoundtoreducetheactivationofnuclearfactorkappalightchainenhancerofactivatedBcells(NF-kB),suppressthephosphorylationofsubunitnuclearfactorkappalightpolypeptidegeneenhancerinBcellsinhibitorα(IkBα)andinhibitsTNF-inducedexpressionofintercellularadhesionmolecule1(ICAM-1)andvascularcelladhesionmolecule1(VCAM-1).Moreover,Boc-D-FMKhasalsoeffectivelyattenuatedthehepatocyteapoptosisinbileduct-ligatedratspotentiallyimprovingthesurvivalrates.
Synonym(s):
CaspaseInhibitorIII;Boc-Asp(OMe)-FMK;Boc-D(OMe)-FMK;Boc-Asp-Fluoromethylketone;methyl5-fluoro-3-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxopentanoate
Purity:
≥98%byHPLC
Solubility:
SolubleinDMSO
Storage/Stability:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.CowburnAS,etal.Blood.2005Apr1;105(7):2970-2.
2.WuX,etal.AmJPhysiolRenalPhysiol.2009Aug;297(2):F316-26.
3.Sheen-ChenSM,etal.JGastroenterolHepatol.2008Aug;23(8Pt1):1276-9.
2.WuX,etal.AmJPhysiolRenalPhysiol.2009Aug;297(2):F316-26.
3.Sheen-ChenSM,etal.JGastroenterolHepatol.2008Aug;23(8Pt1):1276-9.
Notes:
Theinhibitorisdesignedasamethylestertofacilitatecellpermeability.Iftheintendeduseisonpurifiedorrecombinantenzymes,esteraseshouldbeaddedtogeneratefreecarboxylgroups.
AminoAcidSequence:
Boc-Asp(OMe)-CH?F
ScientificCategory:
ApoptosisInhibitor
ProductType:
Inhibitor
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