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商品描述
MW:331.4Da
CASRegistry#:321674-73-1
Formula:C21H17NO3
Target:Telomerase
Background:
IthasbeenreportedthatBIBR1532inhibitedthereversetranscriptaseoftelomerase,hTERT,andshortenedthelengthofthetelomerasetosuppresshumancancercellproliferation.Inpre-Bacutelymphoblasticleukemiacells,BIBR1532suppressedc-MycandhTERTexpressioninaconcentration-dependentmannertoinhibittelomeraseactivity,andhighdosesofBIBR1532couldinduceapoptosisbyelevatingp73,Bax/Bcl-2andcaspase-3activation.InNB4leukemiccells,combinedtreatmentswithBIBR1532andarsenictrioxidesuppressedcellproliferativecapacityandinhibitedtelomeraseactivityprobablyviatranscriptionalsuppressionofc-MycandhTERT.
Description:
BIBR1532isanovel,specifictelomeraseinhibitorwithIC50=93nM.
Synonym(s):
2-[[(E)-3-naphthalen-2-ylbut-2-enoyl]amino]benzoicacid
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
Reference(s):
1.Damm,K.,etal.EMBOJ.2001,20,6958?6968.
2.BashashD.,etal.LeukLymphoma.2013Mar;54[4]:561-8.
3.BashashD.,etal.AnticancerAgentsMedChem.2013Sep;13(7):1115-25.
2.BashashD.,etal.LeukLymphoma.2013Mar;54[4]:561-8.
3.BashashD.,etal.AnticancerAgentsMedChem.2013Sep;13(7):1115-25.
ScientificCategory:
Telomerase
ProductType:
Inhibitor
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