品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
商品描述
MW:394.7Da
CASRegistry#:3543-75-7
Formula:C16H21Cl2N3O2•HCl
Background:
Bendamustineinhibitsmitoticcheckpointsandinducesmitoticcatastrophebyinhibitingseveralmitosis-relatedgenessuchasPolo-likekinase1,AurorakinaseA,andCyclinB1.Inmyelomacelllines,bendamustineinducedapoptosisbycleavageofcaspase3,andresultedinG2cellcyclearrest.Inchroniclymphocyticandmantlecelllymphomacelllines,bendamustineHClhasbeenshowntoactivateboththemitochondrialcelldeathpathwayandcaspase-dependentapoptosis.
Description:
BendamustineHClisanalkylatingagentassociatedwithDNAdamage(IC50=50µM).Itisacytostaticagentthatdisplaysactivityinnon-Hodgkin"slymphomas.
Synonym(s):
4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoicacid
BIOLOGicalActivity:
Bendamustineexhibitedanti-proliferationeffectsondexamethasone-sensitive(MM1.S)and-resistant(MM1.R)multiplemyelomacellsinadose-dependentmanner,withIC50sof119.8µM(MM1.S)and138µM(MM1.R),respectively.Theapoptosisbyactivationofcaspase-3andcaspase-8wasinducedinbothMM1.SandMM1.Rcelllines.
Solubility:
SolubleinDMSO
Storage/StABIlity:
Storeatorbelow–20°C.Solidformisstableatleast12monthsfromdateofreceipt,whenstoredasdirected.Donotstoreaqueoussolutionsformorethanoneday.
ScientificCategory:
ApoptosisInducers
ProductType:
Activator/Inducer
Datashownislot-specific.Contactusforspecificinformationonotherlots.


