870621 | 18:0-PhoDAG
1-stearoyl-2-[(E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl]-sn-glycerol
18:0-PhoDAG
1-stearoyl-2-[(E)-4-(4-((4-butylphenyl)diazenyl)phenyl)butanoyl]-sn-glycerol
Diacylglycerols (DAG) play a key role in transient receptor potential (TRP) channels. TRP channels are linked to a wide variety of biological processes including the body"s ability to sense and process pain, temperature, tastes, pressure, and vision. 18:0 PhoDAG is embedded with a photoswitchable azobenzene moiety that allows rapid photoactivation of these DAG-sensitive TRP channels. The photoswitchable DAG allows for the further exploration of the physiological relevance of these TRP channels in the body’s homeostasis process.
Leinders-Zufall, T., Storch, U., Bleymehl, K.; et. al. PhoDAGs Enable Optical Control of Diacylglycerol-Sensitive Transient Receptor Potential Channels. Cell Chem. Bio. 2020 Dec 21; 2(25): 215-223. https://doi.org/10.1016/j.chem...
C41H64N2O5
C 74.06% H 9.70% N 4.21% O 12.03%
- ChemDraw File
- 3D Structure
- Structure
Zhang X, Barraza KM, Upton KT, Beauchamp JL. Subtle Changes in Lipid Environment Have Profound Effects on Membrane Oxidation Chemistry. J Am Chem Soc. 2018 Nov 21. doi: 10.1021/jacs.8b08610. [Epub ahead of print]
PubMed ID: 30461271- Certificate of Analysis(Lot No. 870621P-25MG-A-010and 6497PJA010)
- Certificate of Analysis(Lot No. 870621P-5MG-A-010and 6497PHA010)
- Certificate of Analysis(Lot No. 870621P-25MG-A-011and 6497PJA011)
- Certificate of Analysis(Lot No. 870621P-5MG-A-011and 6495PHA011)
