DODMA

1,2-dioleyloxy-3-dimethylaminopropane

Cationic lipids such as DODMA are considered non-viral carriers for gene therapy. DODMA is used for the preparation of cationic liposomes or lipid nanoparticles (LNP) needing a neutral or low zeta potential. DODMA is extremely effective at encapsulating nucleic acids due to its ability to temporarily reduce pH.

Zhou Chen, Aili Zhang, Zhaogang Yang, Xinmei Wang, Lingqian Chang, Zhaofeng Chen and Ly James Lee, “Application of DODMA and Derivatives in Cationic Nanocarriers for Gene Delivery”, Current Organic Chemistry (2016) 20: 1813. https://doi.org/10.2174/138527...

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