商品描述
Product nameAdenosine A2A Receptor Functional Recombinant Cell LineCatalog number79381 (2 vials)DescriptionAdenosine A2a receptor (A2aR or ADORA2A) stably expressed in HEK-293 reporter cells with a cAMP-responsive luciferase construct (CRE/CREB Luc, BPS Bioscience, #60515). A2aR is a member of the seven transmembrane G protein-coupled receptor (GPCR) family. The activity of A2aR is mediated by Gs protein which activates adenylyl cyclase, resulting in the synthesis of intracellular cAMP. The level of cAMP correlates with the respective adenosine (agonist) level, and the cell line can be used to measure the EC50 and IC50 values of A2aR agonists or antagonists in a quantitative manner. Binding of extracellular adenosine ligand or its stable analog NECA (5'-(N-Ethylcarboxamido) adenosine) to the A2aR expressed on the surface of this cell line can also produce luciferase reporter signal for qualitative measurement. SourceBPS BioscienceProduct categoryCells, Media & FractionsProduct sub categoryCell LinesBiological activityShipment infoDry IceNacres CodificationNA.81 Tebu-Bio通过我们广泛的完全可定制的服务，在体外模拟人体的生理环境。您指定的项目经理将帮助您定义最佳方法，以建立概念验证，发现和了解NCE和生物制剂的作用机理，获取具有相关生物标志物的证据...我们可以根据您不断变化的需求来处理您的全部或部分项目。所有CRO工作都是在我们通过ISO9001：2015和ISO14001：2015欧洲认证的实验室中秘密进行的，并且有明确但灵活的截止日期。无论您的研究领域是什么，通过外包到tebu-bio，您都可以节省时间和成本，同时确保您完全控制研究和知识产权。
