Overview:

A DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors¹. Like 5’-Azacytidine and decitabine, 2’-Deoxy-5-fluorocytidine is a pyrimidine analog that integrates into chromatin to inhibit DNA methylation². It blocks proliferation in colon cancer-derived HCT116 cells by activating DNA response pathways³. It inhibits various strains of pathogenic avian influenza viruses in vitro and in vivo⁴.

References:

1. J Ren et al. Cell Signal. 2011 23:10822. H Gowher et al. Cancer Biol. Ther. 2004 3:10623. Q Zhao et al. Springerplus 2002 1:654. Y Kumaki et al. Antiviral Res. 2011 92:329