- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
Alpha-synuclein is a member of the synuclein family which also includes beta- and gamma-synuclein. These proteins are abundantly expressed in the brain and alpha- and beta-synuclein selectively inhibit phospholipase D2 which is a highly conserved protein that is also abundant in neurons, especially presynaptic terminals (1). Alpha-synuclein gene is not a major risk factor in familial Parkinson disease (2). Alpha-synuclein may serve to integrate pre-synaptic signaling and membrane trafficking and Alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer"s disease.
Gene Aliases:
NACP; PARK1; PARK4; PD1; SNCA
Genbank Number:
NM_000345
References:
1. Giasson, B. I. et.al: Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 290: 985-989, 2000.2. Markopoulou, K. et.al: Greek-American kindred with autosomal dominant, levodopa-responsive Parkinsonism and anticipation. Ann. Neurol. 38: 373-378, 1995.
