Overview:

Synoviolin (SYVN1/HRD1) is a multispanning membrane protein with its C-terminal RING-H2 finger domain located in the cytoplasm. A member of the E3 ubiquitin-protein ligase family that accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, acting as a part of the ER-associated degradation (ERAD) system involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.

Gene Aliases:

SYVN1 (synoviolin); HRD1; DER3

Genbank Number:

NM_172230

References:

1. Nadav E, et al: A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. Biochem Biophys Res Commun. 2003 303(1):91-7.2. Kikkert M, et al: Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum. J Biol Chem. 2004 279(5):3525-34.