- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
PRPF19 or pre-mRNA-processing factor 19 is the human homolog of yeast Pso4. PRPF19 is a gene essential for cell survival, DNA repair and association with terminal deoxynucleotidyl transferase (1). PRPF19 forms a stable complex with SETMAR (Metnase) which is a SET and transposase fusion protein in humans and plays a positive role in double-strand break (DSB) repair. PRPF19 mediates association of SETMAR with sites of DNA damage (2). SNEV is an orthologue of PRPF19 and is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly.
Gene Aliases:
PSO4; SNEV; PRP19; UBOX4; hPSO4; NMP200
Genbank Number:
NM_014502
References:
1. Mahajan, K. N. et.al: Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. Proc. Nat. Acad. Sci. 100: 10746-10751, 2003.2. Beck, B. D. et.al: Human Pso4 is a Metnase (SETMAR)-binding partner that regulates Metnase function in DNA repair. J. Biol. Chem. 283: 9023-9030, 2008.
