- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
Troponin1 is a member of the tropomyosin family and regulates the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin1 is part of a complex with troponin T and troponin C in which Troponin1 acts as an inhibitory subunit that blocks actin-myosin interactions and thereby mediates striated muscle relaxation (1). Troponin1 is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The Troponin1 protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes (2).
Gene Aliases:
TNNI1; DKFZp451O223; SSTNI; TNN1
Genbank Number:
NM_003281
References:
1. Tiso, N. et al: Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast. Biochem. Biophys. Res. Commun. 230: 347-350, 1997. 2. Nadal-Ginard.et al: Molecular basis of cardiac performance: plasticity of the myocardium generated through protein isoform switches. J. Clin. Invest. 84: 1693-1700,198
