Overview:

PTK7 or pseudo protein tyrosine kinase 7 is a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. PTK7 lacks detectable catalytic tyrosine kinase activity but is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion (1). PTK7 interacts with B-catenin and functions upstream from glycogen synthase kinase 3. PTK7 has been isolated from colon carcinoma and was designated colon carcinoma kinase-4 (2). In conjunction with other T cell markers, PTK7 has utility as a biomarker for detecting minimal residual disease of T-ALL in the bone marrow.

Gene Aliases:

CCK-4; CCK4

Genbank Number:

NM_002821

References:

1. Lu, X.et.al: PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 430: 93-98, 2004. 2. Mossie, K. et.al: Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. Oncogene 11: 2179-2184, 1995.