Overview:

Protein kinase C delta (PKCδ) is a member of the protein kinase C (PKC) family of serine-threonine kinases. It is a 79 kd protein kinase that shows strict dependence on the presence of phospholipids, but shows no activation by Ca2+ (1). Phosphatidylinositol is the most potent activator of PKC delta. Northern blot analysis indicated that PKCdelta is widely distributed in almost all the tissues and is a major isoform of PKC expressed in hemopoietic cells (2). PKCdelta is involved in fundamental cellular functions regulated by diacylglycerols and mimicked by phorbol esters.

Gene Aliases:

PRKCD; MAY1; MGC49908; nPKC-delta

Genbank Number:

NM_006254

References:

1. Leibersperger, H. et al: Immunological demonstration of a calcium-unresponsive protein kinase C of the delta-type in different species and murine tissues. Predominance in epidermis. J Biol Chem. 1991 Aug 5;266(22):14778-84.2. Mischak, H. et al: Mouse protein kinase C-delta, the major isoform expressed in mouse hemopoietic cells: sequence of the cDNA, expression patterns, and characterization of the protein. Biochemistry. 1991 Aug 13;30(32):7925-31.