- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
SMAD9orSMADfamilymember9isamemberoftheSMADfamily.SMAD9transducessignalsfromTGF-betafamilymemberswhichregulategrowth,differentiation,apoptosis,anddevelopment.SMAD9isactivatedbybonemorphogeneticproteinsanditinteractswithSMAD4(1).SMAD9positivelyandnegativelyregulateBMPsignaling,respectively.SMAD9,alsoknownasSMAD8mayplayaroleinbothpulmonaryhypertensionandlungtumOrigenesis(2).MutationsinSMAD9inpatientwithpulmonaryarterialhypertension(PAH)havebeenidentifiedandthismaybeinvolvedinthepathogenesisofPAH.
GeneAliases:
MADH6;MADH9;SMAD8;SMAD8A;SMAD8B
GenbankNumber:
NM_001127217
References:
1.Nishita,M.et.al:Smad8B,aSmad8splicevariantlackingtheSSXSsitethatinhibitsSmad8-mediatedsignalling.GenesCells4:583-591,1999.2.Huang,Z.et.al:DefectivepulmonaryvascularremodelinginSmad8mutantmice.Hum.Molec.Genet.18:2791-2801,2009.
