- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
SMAD5isamemberoftheSMADfamilyandmediatessignalingbythetransforminggrowthfactor-beta(TGFβ)superfamilyandrelatedligands(1).SMAD5playsacriticalroleinthesignalingpathwaybywhichTGFβinhibitstheproliferationofhumanhematopoieticProgenitorcells.SMAD5isup-regulatedingastricepithelialcellsduringtheinfectionofthepathogenHelicobacterpylorianditmediatesapoptosisofgastricepithelialcellsinducedbyH.pyloriinfection(2).InmaturehumanBcells,bonemorphogeneticprotein6(BMP-6)inhibitscellgrowthandrapidlyinducesphosphorylationofSMADs5and8.
GeneAliases:
Dwfc,JV5-1,MADH5,DKFZp781C1895,DKFZp781O1323
GenbankNumber:
NM_005903
References:
1.Heldin,C.H.etal:TGF-betasignallingfromcellmembranetonucleusthroughSMADproteins".Nature,1997,390(6659):465–71.2.Nagasko,T.etal:Up-regulatedSmad5mediatesapoptosisofgastricepithelialcellsinducedbyHelicobacterpyloriinfection.JBiolChem.2003Feb14;278(7):4821-5.
