- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
SMAD3isadirectmediatoroftranscriptionalactivationbytheTGFreceptor.TheactivityofSMAD3isregulatedbytheTGFreceptors,andSMAD3isphosphorylatedandassociatedwiththeligand-boundreceptorcomplex.TGFstimulationleadstophosphorylationandactivationofSMAD3,whichformacomplexwithSMAD4thataccumulateinthenucleusandregulatetranscriptionoftargetgenessuchasCDKinhibitor(1).SMAD3containingaC-terminaltruncationactsasadominant-negativeinhibitorofthenormalTGFresponse.SMAD3isamajorphysiologicsubstrateoftheG1cyclin-dependentkinasesCDK4andCDK2(2).
GeneAliases:
MADH3,JV15-2,HSPC193,HsT17436,MGC60396,KFZP586N0721,DKFZp686J10186
GenbankNumber:
NM_005902
References:
1.Inman,G.J.etal:NucleocytoplasmicshuttlingofSmads2,3,and4permitssensingofTGF-betareceptoractivity.Molec.Cell10:283-294,2002.2.Matsuura,I.etal:Cyclin-dependentkinasesregulatetheantiproliferativefunctionofSmads.Nature430:226-231,2004.
