- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
p16INK4Aproteinfamilyspecificallyinhibitcyclin-dependentkinase4-mediatedphosphorylationoftheretinoblastoma(Rb)susceptibilitygeneproduct.p16INK4A,hasbeenidentifiedasatumorsuppressorinmanyhumancancersandinactivationofp16INK4AintumorsisthoughttoberequiredinorderformanymalignantcelltypestoenterS-phase(1).p16INK4Aexpressionisrequiredforthereductionincdk4-andcdk6-mediatedRbkinaseactivityobservedinresponsetoDNAdamage.p16INK4Ageneisfrequentlymutatedordeletedinawidevarietyoftumors,andisknowntobeanimportanttumorsuppressorgene(2).
GeneAliases:
CDKN2A,ARF,MLM,p14,p16,p19,CMM2,INK4,MTS1,TP16,CDK4I,CDKN2,INK4a,p14ARF,p16INK4
GenbankNumber:
NM_000077
References:
1.Smith-Sørensen,B.etal:CDKN2A(p16INK4A)somaticandgermlinemutations.Hum.Mutat.1996;7(4):294-303.2.Kusy,S.etal:p14ARF,p15INK4bandp16INK4amethylationstatusinchronicmyelogenousleukemia.Leuk,Lymphoma,2005;45(10):1989-94.
