- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
GSK3αisamultifunctionalproteinserinekinase,homologoustoDrosophila"shaggy"(zeste-white3)andimplicatedinthecontrolofseveralregulatoryproteinsincludingglycogensynthaseandtranscriptionfactors(e.g.,JUN)(1).GSK3αalsoplaysaroleintheWNTandPI3Ksignalingpathways.Alzheimerdiseaseisassociatedwithincreasedproductionandaggregationofamyloid-beta-40and-42peptidesintoplaques.GSK3αisrequiredformaximalproductionofthebeta-amyloid-40and-42peptidesgeneratedfromtheamyloidprecursorproteinbypresenilin-dependentgamma-secretasecleavage.Invitro,lithium,aGSK3αinhibitor,blockstheproductionofthebeta-amyloidpeptidesbyinterferingwiththegamma-secretasestep(2).
References:
1.Ali,A.etal:Glycogensynthasekinase-3:properties,functions,andregulation.Chem.Rev.101:2527-2540,2001.2.Phiel,CJ.etal:GSK-3-alpharegulatesproductionofAlzheimer"sdiseaseamyloid-betapeptides.Nature423:435-439,2003.
