- 细胞因子
- Dihydropyrimidinase and Proteins
- Regulatory proteins
- 授予称号
- Peptide Substrates
- Isoform Specific Antibodies
- Deacetylase & Demethylase Proteins
- Acetyl & Methyltransferase Proteins
- siRNA Controls
- Cell Stress and Chaperone Proteins
- 激酶
- 双加氧酶与蛋白质
- Transcription Proteins
- Carbohydrate Kinases
- 表观遗传酶抑制剂
- Growth Factors
- 脂类激酶
- Phospholipase C and Proteins
- Mutant Kinases
- Oligo Substrates
- Fluorescent and Color Proteins
Overview:
Thetranslationalrepressorprotein4EBP1interactsdirectlywitheukaryotictranslationinitiationfactor4E(EIF4E).Thisinteractioninhibitstheformationofthemulti-subunitcomplexthatrecruits40Sribosomalsubunitstothe5"endofmRNAsthuspreventingcap-dependenttranslation.Hyperphosphorylationof4EBP1disruptsitsbindingwithEIF4E(1).TreatingADIposecellswithinsulinleadstoincreased4EBP1phosphorylation(1).4EBP1isexpressedinmosttissues,withhighlevelsdetectedinadiposetissue,pancreasandskeletalmuscle(2).4EBP1isphosphorylatedatseveralresiduesincludingThr45inresponsetothephorbolesterTPA.
References:
1.Pause,A.etal:Insulin-dependentstimulationofproteinsynthesisbyphosphorylationofaregulatorof5-prime-capfunction.Nature371:762-767,1994.,br>2.Tsukiyama-Kohara,K.etal:Tissuedistribution,genomicstructure,andchromosomemappingofmouseandhumaneukaryoticinitiationfactor4E-bindingproteins1and2.Genomics38:353-363,1996.
