Overview:

PDGFRα (platelet-derived growth factor receptor a) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. Aberrant expression of PDGFRα has been linked to developmental abnormalities in vertebrate models and has been implicated in multiple disease states in humans. There is widespread expression of PDGFRα in renal cell types involved in fibrotic and sclerosing processes(1). PDGF and its receptor PDGFRα are inducers of fibrosis in the repair phase of inflammatory bowel disease and they may also be involved in the active inflammatory phase (2). PDGFRa(T674I) is one of the mutant forms of PDGFRa.

Gene Aliases:

CD140A, PDGFR2, MGC74795, Rhe-PDGFRA

Genbank Number:

NM_006206

References:

1. Floege, J. et al: Expression of PDGF alpha-receptor in renal arteriosclerosis and rejecting renal transplants. J Am Soc Nephrol. 1998 Feb;9(2):211-23.2. Kumagai, S. et al: Platelet-derived growth factor and its receptors are expressed in areas of both active inflammation and active fibrosis in inflammatory bowel disease. Tohoku J Exp Med. 2001 Sep;195(1):21-33.