- 细胞因子
- Dihydropyrimidinase and Proteins
- Regulatory proteins
- 授予称号
- Peptide Substrates
- Isoform Specific Antibodies
- Deacetylase & Demethylase Proteins
- Acetyl & Methyltransferase Proteins
- siRNA Controls
- Cell Stress and Chaperone Proteins
- 激酶
- 双加氧酶与蛋白质
- Transcription Proteins
- Carbohydrate Kinases
- 表观遗传酶抑制剂
- Growth Factors
- 脂类激酶
- Phospholipase C and Proteins
- Mutant Kinases
- Oligo Substrates
- Fluorescent and Color Proteins
/5 ug/E10-132WG-05
Overview:
EGFRisthereceptorformembersoftheEGFfamilyandisatransmembraneglycoproteinthathastyrosinekinaseactivity.BindingofepidermalgrowthfactortoEGFRinducesreceptordimerizationandtyrosineautophosphorylationandleadstocellproliferation,differentiation,motility,andcellsurvival(1).ActivationofEGFRtriggersmitogenicsignalingingastrointestinalmucosa,anditsexpressionisupregulatedincoloncancersandmostneoplasms(2).ActivationofEGFRtriggersactivationoftheERK-signalingpathwayinnormalgastricepithelialandcoloncancercelllines.InactivationofEGFRwithselectiveinhibitorssignificantlyreducesERK2activation,c-fosmRNAexpressionandcellproliferation.
GeneAliases:
ERBB,mENA,ERBB1,HER1
GenbankNumber:
NM_005228
References:
1.WangK,etal:Epidermalgrowthfactorreceptor-deficientmicehavedelayedprimaryendochondralossificationbecauseofdefectiveosteoclastrecruitment.J.Biol.Chem.279:53848-53856,2004.2.KobayashiS,etal:EGFRmutationandresistanceofnon-small-celllungcancertogefitinib.NewEng.J.Med.352:786-792,2005.
