- Peptide Substrates
- Binding Proteins
- Secondary Antibodies
- Regulatory proteins
- 脂类激酶
- 双加氧酶与蛋白质
- 脂质底物
- E2
- Assay Buffer and Co-factors
- Methyltransferases
- Acetyltransferases
- Transcription Proteins
- COVID-19 ELISA Kits
- Tau Proteins
- Microtubule & Actin Associated Proteins
- Carbohydrate Substrates
- COVID-19 Proteins
- Chemokines
- 标记抗体
- 授予称号
- E3
Overview:
BTK(alsoknownasBrutontyrosinekinase)playsacrucialroleinB-lymphocytedifferentiationandactivation.BTKinteractswithSRChomology3domainsofFYN,LYNandHCKthatareactivateduponstimulationofB-andT-cellreceptors(1).DefectsintheBTKgenecauseAgammaglobulinemia,anX-linkedimmunodeficiencycharacterizedbyfailuretoproducematureBlymphocytecellsandassociatedwithafailureofIgheavychainrearrangement.TheuniqueroleofBTKmakesitadesirabletargetforpotentialanti-cancer,anti-inflammatoryandanti-viralagentsaswellasothertreatments(2).
GeneAliases:
AT;ATK;BPK;XLA;IMD1;AGMX1;PSCTK
GenbankNumber:
NM_000061
References:
1.Cheng,G.etal:BindingofBruton"styrosinekinasetoFyn,Lyn,orHckthroughaSrchomology3domain-mediatedinteraction.Proc.Nat.Acad.Sci.91:8152-8155,1994.2.Vassilev,AO.etal:TherapeuticpotentialofinhibitingBruton"styrosinekinase,(BTK).CurrPharmDes.2004;10(15):1757-66.