- 细胞因子
- Dihydropyrimidinase and Proteins
- Regulatory proteins
- 授予称号
- Peptide Substrates
- Isoform Specific Antibodies
- Deacetylase & Demethylase Proteins
- Acetyl & Methyltransferase Proteins
- siRNA Controls
- Cell Stress and Chaperone Proteins
- 激酶
- 双加氧酶与蛋白质
- Transcription Proteins
- Carbohydrate Kinases
- 表观遗传酶抑制剂
- Growth Factors
- 脂类激酶
- Phospholipase C and Proteins
- Mutant Kinases
- Oligo Substrates
- Fluorescent and Color Proteins
/10 ug/B10-12GH-10
Overview:
BTK(alsoknownasBrutontyrosinekinase)playsacrucialroleinB-lymphocytedifferentiationandactivation.BTKinteractswithSRChomology3domainsofFYN,LYNandHCKthatareactivateduponstimulationofB-andT-cellreceptors(1).DefectsintheBTKgenecauseAgammaglobulinemia,anX-linkedimmunodeficiencycharacterizedbyfailuretoproducematureBlymphocytecellsandassociatedwithafailureofIgheavychainrearrangement.TheuniqueroleofBTKmakesitadesirabletargetforpotentialanti-cancer,anti-inflammatoryandanti-viralagentsaswellasothertreatments(2).
GeneAliases:
AT;ATK;BPK;XLA;IMD1;AGMX1;PSCTK
GenbankNumber:
NM_000061
References:
1.Cheng,G.etal:BindingofBruton"styrosinekinasetoFyn,Lyn,orHckthroughaSrchomology3domain-mediatedinteraction.Proc.Nat.Acad.Sci.91:8152-8155,1994.2.Vassilev,AO.etal:TherapeuticpotentialofinhibitingBruton"styrosinekinase,(BTK).CurrPharmDes.2004;10(15):1757-66.
