- 细胞因子
- Dihydropyrimidinase and Proteins
- Regulatory proteins
- 授予称号
- Peptide Substrates
- Isoform Specific Antibodies
- Deacetylase & Demethylase Proteins
- Acetyl & Methyltransferase Proteins
- siRNA Controls
- Cell Stress and Chaperone Proteins
- 激酶
- 双加氧酶与蛋白质
- Transcription Proteins
- Carbohydrate Kinases
- 表观遗传酶抑制剂
- Growth Factors
- 脂类激酶
- Phospholipase C and Proteins
- Mutant Kinases
- Oligo Substrates
- Fluorescent and Color Proteins
Overview:
GSK3αisamultifunctionalproteinserinekinase,homologoustoDrosophila"shaggy"(zeste-white3)andimplicatedinthecontrolofseveralregulatoryproteinsincludingglycogensynthaseandtranscriptionfactors(e.g.,JUN)(1).GSK3αalsoplaysaroleintheWNTandPI3Ksignalingpathways.Alzheimerdiseaseisassociatedwithincreasedproductionandaggregationofamyloid-beta-40and-42peptidesintoplaques.GSK3αisrequiredformaximalproductionofthebeta-amyloid-40and-42peptidesgeneratedfromtheamyloidprecursorproteinbypresenilin-dependentgamma-secretasecleavage.Invitro,lithium,aGSK3αinhibitor,blockstheproductionofthebeta-amyloidpeptidesbyinterferingwiththegamma-secretasestep(2).
References:
1.Ali,A.etal:Glycogensynthasekinase-3:properties,functions,andregulation.Chem.Rev.101:2527-2540,2001.2.Phiel,CJ.etal:GSK-3-alpharegulatesproductionofAlzheimer"sdiseaseamyloid-betapeptides.Nature423:435-439,2003.
