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苏州工业园区生物纳米园A4#216
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商品描述
| Quantity/Tests | 100µg |
| Species/Antigen | HumanIgA1hingeregionpeptidewithGalNAc |
| Host | Rat |
| Subclass/Clone | IgG |
| Type | Polyclonal |
| Purification | ProteinA |
| Label | No |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Anti-humanGd-IgA1(KM55)RatIgG
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化，例如细胞遗传学（核型分析和FISH）和分子细胞遗传学（aCGH /阵列比较基因组杂交），其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段，从标准化工作站，经过验证的应用程序和专用用户界面，到与Tecan Labwerx合作开发的高度定制的平台。 "Originalarticle#10777
Galactose-deficientIgA1(Gd-IgA1)attractsalotofattentionsasacriticaleffectormoleculeinthepathogenesisandprogressionofIgAnephropathy(IgAN)inrecentstudies.IthasbeensuggestedthatseveralO-linkglycansmodifiedregionsexistintheheavychainhingeregionofhumanIgA1moleculeandGd-IgA1circulatesinthebloodstreamofpatientswiththepathologicalconditionofIgAN.ThedepositionofGd-IgA1inglomeruliisconsideredtobeinvolvedinIgAN(Multi-hitHypothesisofGd-IgA1).Themeasuringsystemusingsnail(Helixaspersa;HAA)lectinthatisextractedfromsnailandGd-IgA1ELISA(Code:27600Gd-IgA1(Galactose-deficientIgA1)AssayKitusingthisantibody(KM55)havebeenusedinnumerousstudiesandithasbeensuggestedthatserumlevelsofGd-IgA1inpatientswithIgANissignificantlyelevatedcomparedtothelevelsofhealthysubjectsorpatientswithrenaldiseaseotherthanIgANinsuchstudies.Inaddition,thisantibody(KM55)candetectGd-IgA1intissuebyIHCtechniquedifferentlyfromthefeatureofHAAlectinandithasbeenrevealedthatGd-IgA1specicillayexistsinglomeruliofthepatientsofIgANfromthestudiesusingthisantibody.IthasbeenexpectedthatclinicalsignificanceofGd-IgA1wilberevealedbyfurtherstudiesusingthisantibody."
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Galactose-deficientIgA1(Gd-IgA1)attractsalotofattentionsasacriticaleffectormoleculeinthepathogenesisandprogressionofIgAnephropathy(IgAN)inrecentstudies.IthasbeensuggestedthatseveralO-linkglycansmodifiedregionsexistintheheavychainhingeregionofhumanIgA1moleculeandGd-IgA1circulatesinthebloodstreamofpatientswiththepathologicalconditionofIgAN.ThedepositionofGd-IgA1inglomeruliisconsideredtobeinvolvedinIgAN(Multi-hitHypothesisofGd-IgA1).Themeasuringsystemusingsnail(Helixaspersa;HAA)lectinthatisextractedfromsnailandGd-IgA1ELISA(Code:27600Gd-IgA1(Galactose-deficientIgA1)AssayKitusingthisantibody(KM55)havebeenusedinnumerousstudiesandithasbeensuggestedthatserumlevelsofGd-IgA1inpatientswithIgANissignificantlyelevatedcomparedtothelevelsofhealthysubjectsorpatientswithrenaldiseaseotherthanIgANinsuchstudies.Inaddition,thisantibody(KM55)candetectGd-IgA1intissuebyIHCtechniquedifferentlyfromthefeatureofHAAlectinandithasbeenrevealedthatGd-IgA1specicillayexistsinglomeruliofthepatientsofIgANfromthestudiesusingthisantibody.IthasbeenexpectedthatclinicalsignificanceofGd-IgA1wilberevealedbyfurtherstudiesusingthisantibody."
