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商品描述
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x4h,1x15min |
| Standardrange | 0.5-30ng/mL |
| Specimen/Volumes | 20µLserum,plasma,cellculturesupernatant |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:TGF-beta1(TGF-b1)ELISA
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化，例如细胞遗传学（核型分析和FISH）和分子细胞遗传学（aCGH /阵列比较基因组杂交），其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段，从标准化工作站，经过验证的应用程序和专用用户界面，到与Tecan Labwerx合作开发的高度定制的平台。 Transforminggrowthfactor-beta(TGF-beta)belongstoafamilyofdimeric25kDapolypeptidesthatareubiquitouslydistributedintissuesandsynthesizedbymanydifferentcells.ThreeisoformsoftransformingGrowthFactor-beta(TGF-beta1,beta-2andbeta-3)existinmammals.Theyplaycriticalrolesingrowthregulationanddevelopment.TheTGFbetaspossessthreemajoractivities:theyinhibitproliferationofmostcells,butcanstimulatethegrowthofsomemesechymalcells;theyexertimmunosuppressiveeffectsandtheyenhancetheformationofextracellularmatrix.TheTGF-betasareinvolvedinwoundrepairprocessesandinstartinginflammatoryreactionandthenintheresolutionthroughchemotacticattractionofinflammatorycellsandfibroblast.MeasurementofTGF-beta1inbloodhasbeenadvocatedfordiagnosisofvariousdiseases.TGF-beta1hasbeenshowntobeanorganizerofresponsestoneurodegeneration.Inthiscontext,itturnedouttobeinterestinginmonitoringAlzheimer’sdisease,Down’ssyndrome,AIDSandParkinson’sdisease.SerumandcerebrospinalfluidlevelsofMultipleSclerosispatientswereshowntobeofgreatvaluetomonitorremissionandacutephases.TGF-beta1isthoughttoplayanimportantroleinbonemetabolism,itisconsideredaputativeregulatorofosteoclastic-osteoblasticinteraction,thusitcanberegardedasaMarkerforosteoporosis.TGF-beta1isinvolvedinthepathogenesisofglomerulardiseasessuchasdiabeticnephropathyandglomerulosclerosis.TGF-beta1hasbeendescribedtobefunctionallyconnectedtomajorimmunesystemabnormalitiesasinautoimmunity(SLE).Serumlevelshavebeenshowntocorrelatewithdiseaseactivityinautoimmunehepatitis.ElevatedserumlevelsofTGF-beta1aredeterminedinChronicfatiguesyndromepatientsandinGuillain-Bairesyndromepatients.AninversecorrelationwithdiseaseactivitywasdescribedforTGF-beta1levelsinKawasakidiseaseandpatientswithIgAdeficiency.TGF-beta1hasbeenconfirmedtopromotefibroticprocesses,thusitisimplicatedinthemyelofibrosiswithmyeloidmetaplasia.IncreasedserumlevelsofTGF-beta1inpatientsaffectedbythromboticthromocytopenicpurpuraimplicateitsfunctiononbonemarrowhaematopoiesis.DeterminationofcirculatingTGF-beta1turnedouttoreflectthevariousstagesinsolidtumorsashasbeenshownforcervicalcancer,elevationswerefurThermorefoundinprostaticcancer,bladdercancer,andlivercancer.DecreasedlevelsofTGF-beta1intheserumofsepsisandacutestrokepatientsmayreflectthechangingimmunological-inflammatorystatusofthesepatients.DecreasedTGF-beta1serumlevelsweredescribedforpatientswithacutePlasmodiumfalciparummalaria.
Synonyms:Latency-associatedpeptide(LAP)
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Synonyms:Latency-associatedpeptide(LAP)
