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IBL/MMP-9 (Matrix Metalloprotease-9) ELISA/BE59491/

价格
面议
货号:BE59491
浏览量:118
品牌:IBL
服务
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商品描述
Kitsize12x8
MethodELISA
Incubationtime1x2h;1x1h;1x10min.
Standardrange0.23-15ng/mL
Specimen/Volumes10µLserum,plasma,cellculturesupernatantetal.
Substrate/isotopeTMB450nm
RegulatoryStatus:EU:CE
Detailsfor: MMP-9(MatrixMetalloprotease-9)ELISA
MMP-9isaZn+2dependentendopeptidase,synthesizedandsecretedinmonomericformaszymogen.ThestructureisalmostsimilartoMMP2,anothermemberofmatrixmetalloproteinasefamily.

Likeotherproteolyticenzymes,MMP-9isfirstsynthesizedasinactiveproenzymeorzymogens.ActivationofproMMP-9ismediatedbyplasminogenactivator/plasmin(PA/plasmin)system.TheregulationofMMP-9activityisalsocontrolledthroughTIMP-3.

MMP-9playsanimportantroleintumorinvasion,angiogenesisandmetastasis.IncreasedlevelsofMMP-9havebeendemonstratedincolorectalcancer,inacuteleukemia,breastcancer,humanmelanomaandbladdercancer.MMP-9potentiatespulmonarymetastasisformationandgliomainvasion.Apartfromitsfunctionintumorformationandspread,MMP-9withitsdestructiveeffectsisincloseassociationwithlungdiseasesandasthma.LeukocyterecruitmenttothecentralnervoussystemMMP-9meansaninvolvementinthepathogenesisofmultiplesclerosis.MMP-9hasacrucialroleinreproductiveendocrinologyandshowsachangedexpressionpatternaftermyocardialinfarction.

Synonyms:92kDagelatinase,GelatinaseB,GELB
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
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