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商品描述
Kitsize | 12x8 |
Method | ELISA |
Incubationtime | 1x2h;1x1h;1x10min. |
Standardrange | 0.23-15ng/mL |
Specimen/Volumes | 10µLserum,plasma,cellculturesupernatantetal. |
Substrate/isotope | TMB450nm |
RegulatoryStatus: | EU:CE |
Detailsfor: MMP-9(MatrixMetalloprotease-9)ELISA
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化,例如细胞遗传学(核型分析和FISH)和分子细胞遗传学(aCGH /阵列比较基因组杂交),其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段,从标准化工作站,经过验证的应用程序和专用用户界面,到与Tecan Labwerx合作开发的高度定制的平台。 MMP-9isaZn+2dependentendopeptidase,synthesizedandsecretedinmonomericformaszymogen.ThestructureisalmostsimilartoMMP2,anothermemberofmatrixmetalloproteinasefamily.
Likeotherproteolyticenzymes,MMP-9isfirstsynthesizedasinactiveproenzymeorzymogens.ActivationofproMMP-9ismediatedbyplasminogenactivator/plasmin(PA/plasmin)system.TheregulationofMMP-9activityisalsocontrolledthroughTIMP-3.
MMP-9playsanimportantroleintumorinvasion,angiogenesisandmetastasis.IncreasedlevelsofMMP-9havebeendemonstratedincolorectalcancer,inacuteleukemia,breastcancer,humanmelanomaandbladdercancer.MMP-9potentiatespulmonarymetastasisformationandgliomainvasion.Apartfromitsfunctionintumorformationandspread,MMP-9withitsdestructiveeffectsisincloseassociationwithlungdiseasesandasthma.LeukocyterecruitmenttothecentralnervoussystemMMP-9meansaninvolvementinthepathogenesisofmultiplesclerosis.MMP-9hasacrucialroleinreproductiveendocrinologyandshowsachangedexpressionpatternaftermyocardialinfarction.
Synonyms:92kDagelatinase,GelatinaseB,GELB
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Likeotherproteolyticenzymes,MMP-9isfirstsynthesizedasinactiveproenzymeorzymogens.ActivationofproMMP-9ismediatedbyplasminogenactivator/plasmin(PA/plasmin)system.TheregulationofMMP-9activityisalsocontrolledthroughTIMP-3.
MMP-9playsanimportantroleintumorinvasion,angiogenesisandmetastasis.IncreasedlevelsofMMP-9havebeendemonstratedincolorectalcancer,inacuteleukemia,breastcancer,humanmelanomaandbladdercancer.MMP-9potentiatespulmonarymetastasisformationandgliomainvasion.Apartfromitsfunctionintumorformationandspread,MMP-9withitsdestructiveeffectsisincloseassociationwithlungdiseasesandasthma.LeukocyterecruitmenttothecentralnervoussystemMMP-9meansaninvolvementinthepathogenesisofmultiplesclerosis.MMP-9hasacrucialroleinreproductiveendocrinologyandshowsachangedexpressionpatternaftermyocardialinfarction.
Synonyms:92kDagelatinase,GelatinaseB,GELB