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商品描述
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x30min,2x15min |
| Standardrange | 1-300IU/ml;cut-off:15IU/ml |
| Specimen/Volumes | 10µLserum |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Annexin-VIgG/IgMELISA
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化，例如细胞遗传学（核型分析和FISH）和分子细胞遗传学（aCGH /阵列比较基因组杂交），其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段，从标准化工作站，经过验证的应用程序和专用用户界面，到与Tecan Labwerx合作开发的高度定制的平台。 AnnexinIgG/IgMELISAisasolidphaseenzymeimmunoassayforthequantitativeandqualitativedetectionofIgGand/orIgMantibodiesagainstAnnexinVinhumanserum.TheassayemploysnativehumanAnnexinV.Theassayisatoolinthediagnosisoftheantiphospholipidsyndrome.AntibodiestargetingAnnexinVbelongtothefamilyofantiphospholipidantibodiesincludingforexampleanti-Cardiolipin,ß2-glycoproteinI(ß2-GPI)andProthrombinantibodiesandareassociatedwithprimaryandsecondaryantiphospholipidsyndrome(APS).Clinically,theAPSischaracterizedbyvenousandarterialthrombosisandseverepregnancycomplications.Anti-AnnexinVantibodieshavebeendetectedinpatientswithsystemicautoimmunediseases,especiallysystemiclupuserythematosus,buthavealsobeenassociatedtointrauterinefetalloss,recurrentabortionsandpreeclampsiainAPSpatients.AnnexinVisaCa2+-dependent,phospholipid-bindingproteinwithpotentanticoagulantactivitythatisabundantincellsexposedtoblood,suchasplatelets,trophoblasts,andendothelialcells.ThehighconcentrationofannexinVinplacentalsyncytiotrophoblastshasbeenproposedasamechanismtomaintainbloodfluidityonthesurfaceoftheplacentaandplacentalintergrity.ItthereforeunsuressupplyofthefoetuswithnutrientsandfetalviABIlity.ThrombosisandpregnancylossintheantiphospholipidsyndromemaybecausedbydisruptionofthisAnnexinVshieldbyantiphospholipidantibodiesleADIngtoanincreaseinthequantityofthrombogenicphospholipidsexposedtothecirculatingblood.Anti-AnnexinVautoantibodiesaresupposedtointerferewiththeanticoagulantfunctionofAnnexinVcausingplacentalthrombosisanddisruption.Consequently,thedetectionofanti-AnnexinantibodiesshouldbeincludedintheSEROlogicaldiagnosisofAPSespeciallyinfemalepatientsatriskforobstetriccomplications.
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