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IBL/ANA HEp-2 Screen ELISA/RE70151/

价格
¥5220.00
货号:RE70151
浏览量:127
品牌:IBL
服务
全国联保
正品保证
正规发票
签订合同
商品描述
Kitsize12x8
MethodELISA
Incubationtime3x30min
Standardrangecut-offcontrol
Specimen/Volumes10µLserum
Substrate/isotopeTMB450nm
RegulatoryStatus:EU:CE
Detailsfor: ANAHEp-2ScreenELISA
ANA-HEp2ScreenELISAisasolidphaseenzymeimmunoassayforthecombinedqualitativedetectionofIgGantibodiesagainstHEp2cellsinhumanserum.EachwelliscoatedwithlysedHEp2cells.Thetestcollectivelydetects,inonewell,totalANAsagainstdoublestrandedDNA(dsDNA),histones,SS-A(Ro),SS-B(La),Sm,snRNP/Sm,Scl-70,PM-Scl,Jo-1andcentromericantigensalongwithserapositiveforHEp2immunofluorescencetest(IFT).Theassayisatoolinthedifferentialdiagnosisofsystemicrheumaticdiseaseslikesystemiclupuserythematosus(SLE),mixedconnectivetissuediseases(MCTD),scleroderma,Sjögren`ssyndrome,polymyositisanddermatomyositis.Anti-nuclearantibodies(ANA)directedagainstavarietyofnuclearandcytoplasmicantigensoccurinhighfrequencyinsystemicrheumaticdiseasesandthusareanimportanttoolforthedifferentialdiagnosis.Forinstance,SS-A(Ro)andSS-B(La)antibodiesareassociatedwithSLEandSjögren’ssyndrome(SS),anti-dsDNAandanti-SmantibodieswithSLE,anti-histoneantibodieswithSLEanddrug-inducedlupus,anti-RNPantibodieswithmixedconnectivetissuedisease(MCTD)andSLE,anti-Scl-70antibodieswithscleroderma(progressivesystemicsclerosis[PSS]),anti-Jo-1antibodieswithpolymyositisanddermatomyositisandanti-centromereantibodieswithCRESTsyndrome.Indirectimmunofluorescencetest(IFT)oneucaryoticcellslikeHeLaandHEp2hasbeentheestablishedmethodforthedetectionofANAs.AlthoughtheIFTisasensitivetest,itislaboriouswhentestinglargenumbersofpatientsamplesandissubjecttoerrorsfromhumaninterpretationandfromvariABIlityinfluorescentmicroscope.TheELISAtestsystemisanexcellentalternativetotheIFTforscreeningpatient`sserumforthepresenceofANAsofclinicalsignificance.SingleantibodyspecificitieshavetobedeterminedbymorespecifictestingusingELISAsemployingthespecifictargetantigensforasimpleandreliabledifferentiationofANAs.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化,例如细胞遗传学(核型分析和FISH)和分子细胞遗传学(aCGH /阵列比较基因组杂交),其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段,从标准化工作站,经过验证的应用程序和专用用户界面,到与Tecan Labwerx合作开发的高度定制的平台。