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商品描述
Kitsize | 12x8 |
Method | ELISA |
Incubationtime | 1x2h,1x10min |
Standardrange | 2.3-150U/mL |
Specimen/Volumes | 10µLserum,plasma,cellculturesupernatantetal. |
Substrate/isotope | TMB450nm |
RegulatoryStatus: | Forresearchuseonly |
Detailsfor: sP-Selectin(monkey)ELISA
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化,例如细胞遗传学(核型分析和FISH)和分子细胞遗传学(aCGH /阵列比较基因组杂交),其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段,从标准化工作站,经过验证的应用程序和专用用户界面,到与Tecan Labwerx合作开发的高度定制的平台。 P-selectinbelongstotheselectinfamilyofadhesionmolecules.P-selectinactsasareceptorthatsupportsbindingofleukocytestoactivatedplateletsandendothelium.P-selectinisa140kDaproteinthatishighlyglycosylated.TheCDNAderivedaminoacidsequencepredictsamoleculewithaseriesofcysteine-richdomains.P-selectinislocatedinmembranesofagranulesinunstimulatedplateletsandredistributedtothecellsurfaceuponplateletactivation.P-selectinisalsopresentinendothelialcellsinmembranesofWeibel-Paladebodiesandmegakaryocytes.ThephysiologicroleofP-selectinmightbethemediationofinitialleukocyteadhesiontoactivatedendotheliumduringacuteinflammation.ItmayworkinconcertwithE-selectintodirectearly,regionallyspecificadherenceofneutrophilsandmonocytesatsitesofacuteinflammation.AsolubleformofP-selectinfoundinserumandplasmahasbeendescribedwhichmightrepresentaproteolyticfragmentormorelikelyasolublesplicevariantlackingthetransmembranedomain.
ExcessiveaccumulationofneutrophilsontheendothelialsurfaceaccompaniedbyhighexposureofP-selectinhasbeenimplicatedinanumberofinflammatorydisorders,includingadultrespiratorydistresssyndrome,acutelunginjury,ischemia-reperfusioninjury,Gram-negativesepticshock,thromboticdiseasesandrheumatoidarthritis.MalignantcellswereshowntoexpressreceptorsforP-selectinsuggestinganimportantroleforP-selectinintumorformationandmetastasis.
Synonyms:Granulemembraneprotein140,PADGEM,CD62P
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.ExcessiveaccumulationofneutrophilsontheendothelialsurfaceaccompaniedbyhighexposureofP-selectinhasbeenimplicatedinanumberofinflammatorydisorders,includingadultrespiratorydistresssyndrome,acutelunginjury,ischemia-reperfusioninjury,Gram-negativesepticshock,thromboticdiseasesandrheumatoidarthritis.MalignantcellswereshowntoexpressreceptorsforP-selectinsuggestinganimportantroleforP-selectinintumorformationandmetastasis.
Synonyms:Granulemembraneprotein140,PADGEM,CD62P