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| Type | recombinantprotein |
| AvailableSizes | 500µg |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:BoxAfromHMGB1,human&mouse,LPS-free-500µg
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化，例如细胞遗传学（核型分析和FISH）和分子细胞遗传学（aCGH /阵列比较基因组杂交），其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段，从标准化工作站，经过验证的应用程序和专用用户界面，到与Tecan Labwerx合作开发的高度定制的平台。 BoxAisoneofthehighlyconservedDNAbindingdomainsofHMGB1protein(HMGboxes).
BoxAisanantagoNISTforHMGB1bindingtoitsreceptorRAGE,andinhibitsHMGB1cytokineeffectsinvivo.TheBoxAweprovidehasnodifferencefromthesequenceofthehumanormouseHMGB1,andasaself-antigenelicitsverylowimmunologicalresponses.
BoxAprotectsagainstsepsisinamouseperitonitismodel(Yangetal.Reversingestablishedsepsiswithantagonistsofendogenoushigh-mobilitygroupbox1.ProcNatlAcadSciUSA2004,101:296-301),andfromhepatitisinamousemodelofHBVinfection(Sitiaetal.TreatmentwithHMGB1inhibitorsdiminishesCTL-inducedliverdiseaseinHBVtransgenicmice.JLeukocBiol2007,81:100-7).
DendriticcellspromotetheirownmaturationandTcellproliferation,survivalandTh1differentiationbysecretingHMGB1,andBoxAinhibitstheseactivities(Dumitriuetal.ReleaseofHMGB1bydendriticcellscontrolsTcellactivationviathereceptorforadvancedglycationendproducts(RAGE).JImmunol2005,174:7506-15).
BoxAalsoinhibitsthechemotacticactivityofHMGB1onendothelialcellsandfibroblasts,andthemitogenicactivityofHMGB1forstemcells(MEBianchi,unpublished).
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.BoxAisanantagoNISTforHMGB1bindingtoitsreceptorRAGE,andinhibitsHMGB1cytokineeffectsinvivo.TheBoxAweprovidehasnodifferencefromthesequenceofthehumanormouseHMGB1,andasaself-antigenelicitsverylowimmunologicalresponses.
BoxAprotectsagainstsepsisinamouseperitonitismodel(Yangetal.Reversingestablishedsepsiswithantagonistsofendogenoushigh-mobilitygroupbox1.ProcNatlAcadSciUSA2004,101:296-301),andfromhepatitisinamousemodelofHBVinfection(Sitiaetal.TreatmentwithHMGB1inhibitorsdiminishesCTL-inducedliverdiseaseinHBVtransgenicmice.JLeukocBiol2007,81:100-7).
DendriticcellspromotetheirownmaturationandTcellproliferation,survivalandTh1differentiationbysecretingHMGB1,andBoxAinhibitstheseactivities(Dumitriuetal.ReleaseofHMGB1bydendriticcellscontrolsTcellactivationviathereceptorforadvancedglycationendproducts(RAGE).JImmunol2005,174:7506-15).
BoxAalsoinhibitsthechemotacticactivityofHMGB1onendothelialcellsandfibroblasts,andthemitogenicactivityofHMGB1forstemcells(MEBianchi,unpublished).
