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商品描述
| Kitsize | 96 |
| Method | RIA(CT) |
| Incubationtime | 1x18h |
| Standardrange | 0.45-47ng/mL |
| Specimen/Volumes | 100µLserum,plasma/extraction |
| Substrate/isotope | 125I<145kBq |
| RegulatoryStatus: | EU:CE |
Detailsfor:SomatomedinCRIA(CT)(IGF-1)
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化，例如细胞遗传学（核型分析和FISH）和分子细胞遗传学（aCGH /阵列比较基因组杂交），其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段，从标准化工作站，经过验证的应用程序和专用用户界面，到与Tecan Labwerx合作开发的高度定制的平台。 Insulin-likegrowthfactorI(IGF-I)isapolypeptideof70aminoacids(7650daltons),andisoneofanumberofrelatedinsulin-likegrowthfactorspresentinthecirculation.Themoleculeshowsapproximately50%sequencehomologywithproinsulinandhasanumberofbiologicalactivitiessimilartoinsulin.Thepeptideisgrowthhormone(GH)dependenttoahighdegree,butthereisgrowingevidenceofGH-independentsecretion.IGF-Ihasnumerousgrowth-promotingeffects,includingmitogeniceffectsandthepromotionofcartilagesulphation.Italsomediatesgrowthpromotingactionsofgrowthhormoneonskeletalandotherbodyfluids.Almostall(>95%)ofserumIGF-IcirculatesboundtospecificIGFbindingproteins,ofwhichsixclasses(IGF-BPs1-6)arenowrecognised.BP3isthoughttobethemajorbindingproteinofIGF-I,formingaternarycomplexof140000daltonswithIGF-Iandanacid-lABIlesub-unit.ThemeasurementofserumIGF-Iisofrecognisedvalueinchildrenwithgrowthdisordersandinthediagnosisandmonitoringofacromegaly.IGF-Iconcentrationschangewithage,nutritionalstatus,bodycompositionandgrowthhormonesecretion.AsinglebasalIGF-Ideterminationisusefulintheassessmentofshortstatureinchildrenandinnutritionalsupportstudiesofacutelyillpatients.Forthediagnosisofacromegaly,asingleIGF-IdeterminationisconsideredmorereliablethanarandomGHdetermination.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
